Eukaryotic systems broaden the scope of synthetic biology

被引：30

作者：

Haynes, Karmella A. ^{[1
]}

Silver, Pamela A. ^{[1
]}

机构：

[1] Harvard Univ, Sch Med, Dept Syst Biol, Boston, MA 02115 USA

来源：

JOURNAL OF CELL BIOLOGY | 2009年 / 187卷 / 05期

基金：

美国国家卫生研究院;

关键词：

GENE-EXPRESSION; MAMMALIAN-CELLS; ESCHERICHIA-COLI; TRANSGENE EXPRESSION; ENDOPLASMIC-RETICULUM; TRANSCRIPTION FACTORS; SIGNALING PATHWAYS; NATURAL RIBOSWITCH; TOGGLE SWITCH; T-ANTIGEN;

D O I：

10.1083/jcb.200908138

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

Synthetic biology aims to engineer novel cellular functions by assembling well-characterized molecular parts (i.e., nucleic acids and proteins) into biological "devices" that exhibit predictable behavior. Recently, efforts in eukaryotic synthetic biology have sprung from foundational work in bacteria. Designing synthetic circuits to operate reliably in the context of differentiating and morphologically complex cells presents unique challenges and opportunities for progress in the field. This review surveys recent advances in eukaryotic synthetic biology and describes how synthetic systems can be linked to natural cellular processes in order to manipulate cell behavior and to foster new discoveries in cell biology research.

引用

页码：589 / 596

页数：8

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