Chemical synthesis of proteins

被引：55
作者：
Borgia, JA [1 ]
Fields, GB
机构：
[1] Florida Atlantic Univ, Dept Chem, Boca Raton, FL 33431 USA
[2] Florida Atlantic Univ, Ctr Mol Biol & Biotechnol, Boca Raton, FL 33431 USA
来源：
TRENDS IN BIOTECHNOLOGY | 2000年 / 18卷 / 06期
关键词：
D O I：
10.1016/S0167-7799(00)01445-1
中图分类号：
Q81 [生物工程学（生物技术）]; Q93 [微生物学];
学科分类号：
071005 ; 0836 ; 090102 ; 100705 ;
摘要：
The manipulation of protein structure enables a better understanding of the principles of protein folding, as well as the development of novel therapeutics and drug-delivery vehicles. Chemical synthesis is the most powerful approach for constructing proteins of novel design and structure, allowing for variation of covalent structure without limitations. Here we describe the various chemical methods that are currently used for creating proteins of unique architecture and function.
引用
收藏
页码：243 / 251
页数：9
相关论文
共 112 条
[1]  
Albericio F, 1997, METHOD ENZYMOL, V289, P313
[2]  
Alewood P, 1997, METHOD ENZYMOL, V289, P14
[3]  
Angeletti RH, 1997, METHOD ENZYMOL, V289, P697
[4]   PEPTIDE-SYNTHESIS .3. COMPARATIVE SOLID-PHASE SYNTHESES OF HUMAN BETA-ENDORPHIN ON POLYAMIDE SUPPORTS USING TERT-BUTOXYCARBONYL AND FLUORENYLMETHOXYCARBONYL PROTECTING GROUPS [J].
ATHERTON, E ;
CAVIEZEL, M ;
FOX, H ;
HARKISS, D ;
OVER, H ;
SHEPPARD, RC .
JOURNAL OF THE CHEMICAL SOCIETY-PERKIN TRANSACTIONS 1, 1983, (01) :65-73
[5]  
Ayers B, 1999, BIOPOLYMERS, V51, P343, DOI 10.1002/(SICI)1097-0282(1999)51:5<343::AID-BIP4>3.0.CO
[6]  
2-W
[7]   CHEMICAL LIGATION OF CYSTEINE-CONTAINING PEPTIDES - SYNTHESIS OF A 22-KDA TETHERED DIMER OF HIV-1 PROTEASE [J].
BACA, M ;
MUIR, TW ;
SCHNOLZER, M ;
KENT, SBH .
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 1995, 117 (07) :1881-1887
[8]   SYNTHESIS OF PROTHYMOSIN ALPHA (PRO T-ALPHA) - A PROTEIN CONSISTING OF 109 AMINO-ACID-RESIDUES [J].
BARLOS, K ;
GATOS, D ;
SCHAFER, W .
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION IN ENGLISH, 1991, 30 (05) :590-593
[9]  
Barnes MJ, 1996, BIOPOLYMERS, V40, P383, DOI 10.1002/(SICI)1097-0282(1996)40:4<383::AID-BIP4>3.0.CO
[10]  
2-S
12345678910