Sepsis-Induced Tissue Hypoperfusion

被引:51
作者
Jones, Alan E. [1 ]
Puskarich, Michael A. [1 ]
机构
[1] Carolinas Med Ctr, Dept Emergency Med, Charlotte, NC 28203 USA
关键词
Sepsis; Septic shock; Resuscitation; Lactate; Hypoperfusion; Infection; Emergency; VENOUS OXYGEN-SATURATION; BENCH-TO-BEDSIDE; PULMONARY-ARTERY CATHETER; BLOOD LACTATE LEVELS; ORGAN FAILURE; SEPTIC SHOCK; SUBLINGUAL CAPNOMETRY; DYSFUNCTION; MORTALITY; MANAGEMENT;
D O I
10.1016/j.ccc.2009.06.003
中图分类号
R4 [临床医学];
学科分类号
1002 ; 100602 ;
摘要
Sepsis affects the cardiovascular system through multiple mechanisms, and often these derangements result in tissue hypoperfusion. Tissue hypoperfusion is often present in the setting of overt shock, but it can also be present in patients without obvious shock physiology. If left untreated, tissue hypoperfusion contributes to the development of multiple organ dysfunction and, ultimately, death. Therefore, it is critical for the clinician to understand the pathophysiology, recognition, and treatment of sepsis-induced hypoperfusion.
引用
收藏
页码:769 / +
页数:12
相关论文
共 68 条
[1]   LACTATE CLEARANCE AND SURVIVAL FOLLOWING INJURY [J].
ABRAMSON, D ;
SCALEA, TM ;
HITCHCOCK, R ;
TROOSKIN, SZ ;
HENRY, SM ;
GREENSPAN, J .
JOURNAL OF TRAUMA-INJURY INFECTION AND CRITICAL CARE, 1993, 35 (04) :584-589
[2]   The role of the endothelium in severe sepsis and multiple organ dysfunction syndrome [J].
Aird, WC .
BLOOD, 2003, 101 (10) :3765-3777
[3]   Epidemiology of severe sepsis in the United States: Analysis of incidence, outcome, and associated costs of care [J].
Angus, DC ;
Linde-Zwirble, WT ;
Lidicker, J ;
Clermont, G ;
Carcillo, J ;
Pinsky, MR .
CRITICAL CARE MEDICINE, 2001, 29 (07) :1303-1310
[4]  
ARDSNET, 2006, NEW ENGL J MED, V354, P2213
[5]   MULTICENTER STUDY OF EARLY LACTATE CLEARANCE AS A DETERMINANT OF SURVIVAL IN PATIENTS WITH PRESUMED SEPSIS [J].
Arnold, Ryan C. ;
Shapiro, Nathan I. ;
Jones, Alan E. ;
Schorr, Christa ;
Pope, Jennifer ;
Casner, Elisabeth ;
Parrillo, Joseph E. ;
Dellinger, R. Phillip ;
Trzeciak, Stephen .
SHOCK, 2009, 32 (01) :35-39
[6]   BLOOD LACTATE LEVELS ARE SUPERIOR TO OXYGEN-DERIVED VARIABLES IN PREDICTING OUTCOME IN HUMAN SEPTIC SHOCK [J].
BAKKER, J ;
COFFERNILS, M ;
LEON, M ;
GRIS, P ;
VINCENT, JL .
CHEST, 1991, 99 (04) :956-962
[7]   Serial blood lactate levels can predict the development of multiple organ failure following septic shock [J].
Bakker, J ;
Gris, P ;
Coffernils, M ;
Kahn, RJ ;
Vincent, JL .
AMERICAN JOURNAL OF SURGERY, 1996, 171 (02) :221-226
[8]   Bench-to-bedside review: Microvascular dysfunction in sepsis - hemodynamics, oxygen transport, and nitric oxide [J].
Bateman, RM ;
Sharpe, MD ;
Ellis, CG .
CRITICAL CARE, 2003, 7 (05) :359-373
[9]   The pursuit of a high central venous oxygen saturation in sepsis: growing concerns [J].
Bellomo, Rinaldo ;
Reade, Michael C. ;
Warrillow, Stephen J. .
CRITICAL CARE, 2008, 12 (02)
[10]  
Bernardin G, 1996, INTENS CARE MED, V22, P17