Macathiohydantoins B-K, novel thiohydantoin derivatives from Lepidium meyenii

被引：17
作者：
Yu, Mu-Yuan [1 ,2 ,3 ]
Qin, Xu-Jie [1 ,3 ]
Peng, Xing-Rong [1 ,3 ]
Wang, Xia [1 ,2 ,3 ]
Tian, Xiao-Xue [1 ,3 ]
Li, Zhong-Rong [1 ,3 ]
Qiu, Ming-Hua [1 ,3 ]
机构：
[1] Chinese Acad Sci, Kunming Inst Bot, State Key Lab Phytochem & Plant Resources West Ch, Kunming 650201, Peoples R China
[2] Univ Chinese Acad Sci, Beijing 100049, Peoples R China
[3] Yunnan Key Lab Nat Med Chem, Kunming 650201, Peoples R China
来源：
TETRAHEDRON | 2017年 / 73卷 / 30期
关键词：
Brassicaceae; Lepidium meyenii; Maca; Thiohydantoin derivatives; MACA; CONSTITUENTS;
D O I：
10.1016/j.tet.2017.05.096
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
Macathiohydantoins B-K (1-10), two new group of naturally occurring thiohydantoin derivatives, together with one known analogues (11), were isolated from the rhizomes of Lepidium meyenii (Maca). Compounds 1-11 were all initially obtained as racemic mixtures and further separated by chiral HPLC chromatography to afford the eleven pairs of enantiomers. The structures of 1-10 including their absolute configurations were fully established by the comprehensive spectroscopic analysis and electronic circular dichroism (ECD) calculations. All isolates were evaluated for their cytotoxic and antimicrobial activities. (C) 2017 Elsevier Ltd. All rights reserved.
引用
收藏
页码：4392 / 4397
页数：6
相关论文
共 21 条
  • [11] Analysis of macamides in samples of Maca (Lepidium meyenii) by HPLC-UV-MS/MS
    McCollom, MM
    Villinski, JR
    McPhail, KL
    Craker, LE
    Gafner, S
    [J]. PHYTOCHEMICAL ANALYSIS, 2005, 16 (06) : 463 - 469
  • [12] Constituents of Lepidium meyenii 'maca'
    Muhammad, I
    Zhao, JP
    Dunbar, DC
    Khan, IA
    [J]. PHYTOCHEMISTRY, 2002, 59 (01) : 105 - 110
  • [13] Investigation of the tuber constituents of maca (Lepidium meyenii Walp)
    Piacente, S
    Carbone, V
    Plaza, A
    Zampelli, A
    Pizza, C
    [J]. JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY, 2002, 50 (20) : 5621 - 5625
  • [14] Neuroprotective effects of Lepidium meyenii (Maca)
    Pino-Figueroa, Alejandro
    Nguyen, Diane
    Maher, Timothy J.
    [J]. NEUROPROTECTIVE AGENTS, 2010, 1199 : 77 - 85
  • [15] Cytotoxic Meroterpenoids with Rare Skeletons from Psidium guajava']java Cultivated in Temperate Zone
    Qin, Xu-Jie
    Yan, Huan
    Ni, Wei
    Yu, Mu-Yuan
    Khan, Afsar
    Liu, Hui
    Zhang, Hong-Xia
    He, Li
    Hao, Xiao-Jiang
    Di, Ying-Tong
    Liu, Hai-Yang
    [J]. SCIENTIFIC REPORTS, 2016, 6
  • [16] Antioxidant activity of the cruciferous vegetable Maca (Lepidium meyenii)
    Sandoval, M
    Okuhama, NN
    Angeles, FM
    Melchor, VV
    Condezo, LA
    Lao, J
    Miller, MJS
    [J]. FOOD CHEMISTRY, 2002, 79 (02) : 207 - 213
  • [17] 1-(methyldithiocarbonyl)imidazole as thiocarbonyl transfer reagent: A facile one-pot three-component synthesis of 3,5-and 1,3,5-substituted-2-thiohydantoins
    Sundaram, G. S. M.
    Venkatesh, C.
    Ila, H.
    Junjappa, H.
    [J]. SYNLETT, 2007, (02) : 251 - 254
  • [18] The in vitro biological activity of Lepidium meyenii extracts
    Valentová, K
    Buckiová, D
    Kren, V
    Peknicová, J
    Ulrichová, J
    Simánek, V
    [J]. CELL BIOLOGY AND TOXICOLOGY, 2006, 22 (02) : 91 - 99
  • [19] Maca: An Andean crop with multi-pharmacological functions
    Wang, Yali
    Wang, Yuchun
    McNeil, Brian
    Harvey, Linda M.
    [J]. FOOD RESEARCH INTERNATIONAL, 2007, 40 (07) : 783 - 792
  • [20] New alkamides from Maca (Lepidium meyenii)
    Zhao, J
    Muhammad, I
    Dunbar, DC
    Mustafa, J
    Khan, IA
    [J]. JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY, 2005, 53 (03) : 690 - 693
123