Macathiohydantoins B-K, novel thiohydantoin derivatives from Lepidium meyenii

被引：17
作者：
Yu, Mu-Yuan [1 ,2 ,3 ]
Qin, Xu-Jie [1 ,3 ]
Peng, Xing-Rong [1 ,3 ]
Wang, Xia [1 ,2 ,3 ]
Tian, Xiao-Xue [1 ,3 ]
Li, Zhong-Rong [1 ,3 ]
Qiu, Ming-Hua [1 ,3 ]
机构：
[1] Chinese Acad Sci, Kunming Inst Bot, State Key Lab Phytochem & Plant Resources West Ch, Kunming 650201, Peoples R China
[2] Univ Chinese Acad Sci, Beijing 100049, Peoples R China
[3] Yunnan Key Lab Nat Med Chem, Kunming 650201, Peoples R China
来源：
TETRAHEDRON | 2017年 / 73卷 / 30期
关键词：
Brassicaceae; Lepidium meyenii; Maca; Thiohydantoin derivatives; MACA; CONSTITUENTS;
D O I：
10.1016/j.tet.2017.05.096
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
Macathiohydantoins B-K (1-10), two new group of naturally occurring thiohydantoin derivatives, together with one known analogues (11), were isolated from the rhizomes of Lepidium meyenii (Maca). Compounds 1-11 were all initially obtained as racemic mixtures and further separated by chiral HPLC chromatography to afford the eleven pairs of enantiomers. The structures of 1-10 including their absolute configurations were fully established by the comprehensive spectroscopic analysis and electronic circular dichroism (ECD) calculations. All isolates were evaluated for their cytotoxic and antimicrobial activities. (C) 2017 Elsevier Ltd. All rights reserved.
引用
收藏
页码：4392 / 4397
页数：6
相关论文
共 21 条
  • [1] [Anonymous], PHCOG RES
  • [2] [Anonymous], 2002, ALTERN THER HEALTH M
  • [3] Flavonolignans and Other Constituents from Lepidium meyenii with Activities in Anti-inflammation and Human Cancer Cell Lines
    Bai, Naisheng
    He, Kan
    Roller, Marc
    Lai, Ching-Shu
    Bai, Lu
    Pan, Min-Hsiung
    [J]. JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY, 2015, 63 (09) : 2458 - 2463
  • [4] SpecDis: Quantifying the Comparison of Calculated and Experimental Electronic Circular Dichroism Spectra
    Bruhn, Torsten
    Schaumloeffel, Anu
    Hemberger, Yasmin
    Bringmann, Gerhard
    [J]. CHIRALITY, 2013, 25 (04) : 243 - 249
  • [5] CHEMICAL-COMPOSITION OF LEPIDIUM-MEYENII
    DINI, A
    MIGLIUOLO, G
    RASTRELLI, L
    SATURNINO, P
    SCHETTINO, O
    [J]. FOOD CHEMISTRY, 1994, 49 (04) : 347 - 349
  • [6] Glucosinolates from Maca (Lepidium meyenii)
    Dini, I
    Tenore, GC
    Dini, A
    [J]. BIOCHEMICAL SYSTEMATICS AND ECOLOGY, 2002, 30 (11) : 1087 - 1090
  • [7] Andean root and tuber crops: Underground rainbows
    Flores, HE
    Walker, TS
    Guimaraes, RL
    Bais, HP
    Vivanco, JM
    [J]. HORTSCIENCE, 2003, 38 (02) : 161 - 167
  • [8] Frisch MJ, 2013, Gaussian 09
  • [9] Chemical profiling and standardization of Lepidium meyenii (Maca) by reversed phase high performance liquid chromatography
    Ganzera, M
    Zhao, JP
    Muhammad, I
    Khan, IA
    [J]. CHEMICAL & PHARMACEUTICAL BULLETIN, 2002, 50 (07) : 988 - 991
  • [10] Glucosinolate contents in maca (Lepidium peruvianum Chacon) seeds, sprouts, mature plants and several derived commercial products
    Li, GY
    Ammermann, U
    Quirós, CF
    [J]. ECONOMIC BOTANY, 2001, 55 (02) : 255 - 262
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