Increased alcohol drinking in isolate-housed alcohol-preferring rats

被引：47

作者：

Ehlers, Cindy L. ^{[1
]}

Walker, Brendan M. ^{[1
]}

Pian, Jerry P. ^{[1
]}

Roth, Jennifer L. ^{[1
]}

Slawecki, Craig J. ^{[1
]}

机构：

[1] Scripps Res Inst, Mol & Integrat Neurosci Dept, La Jolla, CA 92037 USA

来源：

BEHAVIORAL NEUROSCIENCE | 2007年 / 121卷 / 01期

关键词：

risk factors; genetics; environment; ethanol drinking; P and NP rats;

D O I：

10.1037/0735-7044.121.1.111

中图分类号：

B84 [心理学]; C [社会科学总论]; Q98 [人类学];

学科分类号：

03 ; 0303 ; 030303 ; 04 ; 0402 ;

摘要：

Alcoholism is a complex disorder influenced by interactions between genetic and environmental risk factors. This study examined the influence of isolate housing on ethanol intake in alcohol-preferring (P) and non-alcohol-preferring (NP) rats. Rats were isolate-housed or pair-housed for 8 weeks when between 45 and 96 days old. Ethanol drinking was assessed using a 24-hr preference test (10% ethanol vs. water) and 20-min limited access tests. A behavioral test battery was used to assess anxiety-like, depressive-like, acoustic startle, and motor behavior. Isolate housing increased home cage drinking in both lines and increased limited access drinking selectively in P rats. Isolation also reduced swim test immobility and prepulse inhibition in P rats and increased locomotor stereotypies in NP rats. Taken together, these data demonstrate that Line X Environment interactions influence the effects of isolation. Furthermore, isolation selectively increased ethanol intake in high drinking P rats. This effect was not correlated with changes in other behaviors. Selective enhancement of limited access ethanol drinking in P rats may represent a model whereby genetic liability to excessive drinking is enhanced by specific environmental exposures.

引用

页码：111 / 119

页数：9

共 47 条

[1] Seminatural housing increases subsequent ethanol intake in male Maudsley reactive rats [J].

Adams, N ;

Oldham, TD .

JOURNAL OF STUDIES ON ALCOHOL, 1996, 57 (04) :349-351

[2] The effects of isolation rearing on open-field behavior in male rats depends on developmental stages [J].

Arakawa, H .

DEVELOPMENTAL PSYCHOBIOLOGY, 2003, 43 (01) :11-19

[3]

Badia-Elder NE, 2003, ALCOHOL CLIN EXP RES, V27, P894, DOI 10.1111/j.1530-0277.2003.tb04413.x

[4] Discovering the neural basis of human social anxiety: A diagnostic and therapeutic imperative [J].

Charney, DS .

AMERICAN JOURNAL OF PSYCHIATRY, 2004, 161 (01) :1-2

[5] Long-term evaluation of isolation-rearing induced prepulse inhibition deficits in rats [J].

Cilia, J ;

Reavill, C ;

Hagan, JJ ;

Jones, DNC .

PSYCHOPHARMACOLOGY, 2001, 156 (2-3) :327-337

[6] Specific abnormalities in serotonin release in the prefrontal cortex of isolation-reared rats measured during behavioural performance of a task assessing visuospatial attention and impulsivity [J].

Dalley, JW ;

Theobald, DE ;

Pereira, EAC ;

Li, PMMC ;

Robbins, TW .

PSYCHOPHARMACOLOGY, 2002, 164 (03) :329-340

[7]

DEATHERAGE G, 1972, Physiology and Behavior, V9, P55, DOI 10.1016/0031-9384(72)90264-8

[8] Hyperactivity to novelty induced by social isolation is not correlated with changes in D2 receptor function and binding in striatum [J].

Del Arco, A ;

Zhu, SW ;

Terasmaa, A ;

Mohammed, AH ;

Fuxe, K .

PSYCHOPHARMACOLOGY, 2004, 171 (02) :148-155

[9] Serotonin releasers increase prepulse inhibition in serotonin 1B knockout mice [J].

Dulawa, SC ;

Scearce-Levie, KA ;

Hen, R ;

Geyer, MA .

PSYCHOPHARMACOLOGY, 2000, 149 (03) :306-312

[10] Effects of early weaning and social isolation on subsequent alcohol intake in rats [J].

Fahlke, C ;

Hard, E ;

Eriksson, CJP .

ALCOHOL, 1997, 14 (02) :175-180

← 1 2 3 4 5 →