Palliative effect of curcumin on doxorubicin-induced testicular damage in male rats

被引：45

作者：

Aksu, Emrah Hicazi ^{[1
]}

Kandemir, Fatih Mehmet ^{[2
]}

Yildirim, Serkan ^{[3
]}

Kucukler, Sefa ^{[2
]}

Dortbudak, Muhammed Baheeddin ^{[3
]}

Caglayan, Cuneyt ^{[4
]}

Benzer, Fulya ^{[5
]}

机构：

[1] Ataturk Univ, Vet Med Fac, Dept Reprod & Artificial Inseminat, Erzurum, Turkey

[2] Ataturk Univ, Vet Med Fac, Dept Biochem, Erzurum, Turkey

[3] Ataturk Univ, Vet Med Fac, Dept Pathol, Erzurum, Turkey

[4] Bingol Univ, Vet Med Fac, Dept Biochem, Bingol, Turkey

[5] Munzur Univ, Engn Fac, Dept Food Engn, Tunceli, Turkey

来源：

JOURNAL OF BIOCHEMICAL AND MOLECULAR TOXICOLOGY | 2019年 / 33卷 / 10期

关键词：

curcumin; DNA damage; doxorubicin; oxidative stress; testicular toxicity; INDUCED REPRODUCTIVE DAMAGE; OXIDATIVE STRESS; INDUCED TOXICITY; FERTILITY; APOPTOSIS; CHRYSIN; SYSTEM;

D O I：

10.1002/jbt.22384

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

This study aimed to investigate the effect of curcumin (CUR) on doxorubicin (DOX)-induced testicular damage in male rats. Thirty-five adult male Wistar rats were used. Control group was received saline for 7 days. CUR group received CUR for 7 days. DOX group received single dose DOX on the 5th day. DOX+ CUR-100 group received 100 mg/kg/day CUR for 7 days and DOX injection on the 5th day. DOX + CUR-200 group received 200 mg/kg/day CUR for 7 days and DOX injection on the 5th day. DOX treatment decreased in sperm motility rate, live sperm percentages, cellular antioxidants, and increased malondialdehyde (MDA) levels, necrosis, degenerations, and slimming in seminiferous tubules, and DNA damages in testes by inducing oxidative stress. CUR treatment mitigated significantly these side effects when compared with DOX group in a dose-dependent manner. In conclusion, CUR treatment can be used in the mitigation of DOX-induced testicular toxicity.

引用

页数：8

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