Geographic distribution and characteristics of genotype A hepatitis B virus infection in acute and chronic hepatitis B patients in Japan

被引：39

作者：

Ito, Kiyoaki ^{[1
,14
]}

Yotsuyanagi, Hiroshi ^{[2
]}

Sugiyama, Masaya ^{[1
]}

Yatsuhashi, Hiroshi ^{[6
]}

Karino, Yoshiyasu ^{[7
]}

Takikawa, Yasuhiro ^{[8
]}

Saito, Takafumi ^{[9
]}

Arase, Yasuji ^{[3
]}

Imazeki, Fumio ^{[10
]}

Kurosaki, Masayuki ^{[4
]}

Umemura, Takeji ^{[11
]}

Ichida, Takafumi ^{[12
]}

Toyoda, Hidenori ^{[13
]}

Yoneda, Masashi ^{[14
]}

Tanaka, Yasuhito ^{[15
]}

Mita, Eiji ^{[16
]}

Yamamoto, Kazuhide ^{[17
]}

Michitaka, Kojiro ^{[18
]}

Maeshiro, Tatsuji ^{[19
]}

Tanuma, Junko ^{[5
]}

Korenaga, Masaaki ^{[1
]}

Murata, Kazumoto ^{[1
]}

Masaki, Naohiko ^{[1
]}

Koike, Kazuhiko ^{[2
]}

Mizokami, Masashi ^{[1
]}

机构：

[1] Natl Ctr Global Hlth & Med, Res Ctr Hepatitis & Immunol, 1-7-1 Konodai, Ichikawa 2728516, Japan

[2] Univ Tokyo, Grad Sch Med, Dept Internal Med, Tokyo, Japan

[3] Toranomon Gen Hosp, Dept Hepatol, Tokyo, Japan

[4] Musashino Red Cross Hosp, Div Gastroenterol & Hepatol, Tokyo, Japan

[5] Natl Ctr Global Hlth & Med, AIDS Clin Ctr, Tokyo, Japan

[6] NHO Nagasaki Med Ctr, Clin Res Ctr, Nagasaki, Japan

[7] Sapporo Kosei Gen Hosp, Dept Gastroenterol, Sapporo, Hokkaido, Japan

[8] Iwate Med Univ, Dept Internal Med, Div Hepatol, Morioka, Iwate 020, Japan

[9] Yamagata Univ Sch, Dept Gastroenterol, Yamagata, Japan

[10] Chiba Univ, Dept Med & Clin Oncol, Grad Sch Med, Chiba, Japan

[11] Shinshu Univ, Sch Med, Dept Med, Matsumoto, Nagano 390, Japan

[12] Juntendo Univ, Dept Gastroenterol & Hepatol, Shizuoka Hosp, Shizuoka, Japan

[13] Ogaki Municipal Hosp, Dept Gastroenterol, Ogaki, Japan

[14] Aichi Med Univ, Sch Med, Dept Gastroenterol, Nagakute, Aichi 48011, Japan

[15] Nagoya City Univ, Grad Sch Med Sci, Nagoya, Aichi, Japan

[16] Osaka Natl Hosp, Natl Hosp Org, Osaka, Japan

[17] Okayama Univ, Grad Sch Med, Dept Gastroenterol & Hepatol, Okayama 7008530, Japan

[18] Ehime Univ, Grad Sch Med, Dept Gastroenterol, Toon, Japan

[19] Univ Ryukyus, Fac Med, Univ Hosp, Dept Internal Med 1, Nishihara, Okinawa, Japan

来源：

JOURNAL OF GASTROENTEROLOGY AND HEPATOLOGY | 2016年 / 31卷 / 01期

关键词：

acute hepatitis B; chronic hepatitis B; distribution; genotype; human immunodeficiency virus; HEPATOCELLULAR-CARCINOMA; SURFACE-ANTIGEN; HBV INFECTION; CLINICAL-RELEVANCE; RISK-FACTORS; SUBTYPES; MUTATIONS; SEQUENCE; STRAINS; NUCLEOTIDE;

D O I：

10.1111/jgh.13030

中图分类号：

R57 [消化系及腹部疾病];

学科分类号：

摘要：

Background and Aims: The prevalence of sexually transmitted acute infections of the genotype A hepatitis B virus (HBV) has been increasing in Japan. Genotype A HBV is associated with an increased risk of HBV progression to chronic infection after acute hepatitis B (AHB) in adults. A nationwide survey was conducted to evaluate the geographic distribution, clinical, and virologic characteristics of genotype A AHB and chronic hepatitis B (CHB) in Japan. Methods: Five hundred seventy AHB patients were recruited between 2005 and 2010, and 3682 CHB patients were recruited between 2010 and 2011. HBV genotypes were determined for 552 and 3619 AHB and CHB patients, respectively. Clinical characteristics were compared among different genotypes in AHB and CHB patients. Genomic characteristics of HBV genotype A were examined by molecular evolutionary analysis. Results: Hepatitis B virus genotype A was the predominant genotype for AHB between 2005 and 2010. Phylogenetic analysis showed that all strains in the AHB patients with genotype A were classified into subtype Ae. Among CHB patients, the occurrence of genotype A was 4.1%, and genotype A was spreading in young adults. In genotype A CHB patients, early stage liver diseases were predominant, although liver diseases progressed to cirrhosis or hepatocellular carcinoma in some patients. Conclusions: The distribution of HBV genotypes is quite different between AHB and CHB in Japanese patients. Genotype A infection is spreading in young adults of Japanese CHB patients. Sequences derived from Japanese AHB patients were identical to or closely resembled the sequences derived from other Japanese AHB patients.

引用

页码：180 / 189

页数：10

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