The role of innate immunity in the immunopathology and treatment of HBV infection

被引：134

作者：

Maini, Mala K. ^{[1
,2
]}

Gehring, Adam J. ^{[3
]}

机构：

[1] UCL, Div Infect & Immun, Rayne Bldg,5 Univ St, London WC1E 6JF, England

[2] UCL, Inst Immun & Transplantat, London WC1E 6JF, England

[3] St Louis Univ, Sch Med, Mol Microbiol & Immunol, St Louis, MO 63103 USA

来源：

JOURNAL OF HEPATOLOGY | 2016年 / 64卷

基金：

英国惠康基金; 英国医学研究理事会;

关键词：

HBV innate immunity; Innate immunotherapy; Innate sensors; Interferon-alpha; NK cells; MAITs; Monocytes; MDSC; CHRONIC HEPATITIS-B; T-CELL EXHAUSTION; VIRUS-REPLICATION; INTERFERON-ALPHA; NK CELLS; SUPPRESSOR-CELLS; SURFACE-ANTIGEN; HUMAN LIVER; KUPFFER CELLS; BONE-MARROW;

D O I：

10.1016/j.jhep.2016.01.028

中图分类号：

R57 [消化系及腹部疾病];

学科分类号：

摘要：

In this review we give a brief update on sensors recently determined to be capable of detecting HBV, and examine how the virus represses the induction of pro inflammatory cytokines like type I interferons. We overview cellular components of innate immunity that are present at high frequencies in the liver, and discuss their roles in HBV control and/or pathogenesis. We argue that many innate effectors have adaptive like features or can exert specific effects on HBV through immunoregulation of T cells. Finally we consider current and possible future strategies to manipulate innate immunity as novel approaches towards a functional cure for HBV. (C) 2016 Published by Elsevier B.V. on behalf of the European Association for the Study of the Liver.

引用

页码：S60 / S70

页数：11

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