Oleaginous yeast for biofuel and oleochemical production

被引：82

作者：

Spagnuolo, Michael ^{[1
]}

Yaguchi, Allison ^{[1
]}

Blenner, Mark ^{[1
]}

机构：

[1] Clemson Univ, Dept Chem & Biomol Engn, Clemson, SC 29634 USA

来源：

CURRENT OPINION IN BIOTECHNOLOGY | 2019年 / 57卷

基金：

美国国家科学基金会;

关键词：

SINGLE-CELL OIL; VOLATILE FATTY-ACIDS; LIPID PRODUCTION; YARROWIA-LIPOLYTICA; LIPOMYCES-STARKEYI; CRUDE GLYCEROL; RHODOSPORIDIUM-TORULOIDES; CONSTITUTIVE PROMOTERS; CRYPTOCOCCUS-CURVATUS; MICROBIAL LIPIDS;

D O I：

10.1016/j.copbio.2019.02.011

中图分类号：

Q5 [生物化学];

学科分类号：

071010 ; 081704 ;

摘要：

Current transportation fuels derived from petroleum can also be made from microbial systems. In particular, oleaginous yeast have naturally evolved high flux pathways for fatty acids in the form of neutral lipids, which can be converted into a variety of drop-in fuels. Here, we describe the recent advances in the use of the four most popular oleaginous yeasts for making lipids and other potential fuels - Yarrowia lipolytica, Lipomyces starkeyi, Rhodosporidium toruloides, and Cutaneotrichosporon oleaginosus. The paper is divided into three major sections focusing on (1) the important natural complex phenotypes of each yeast; (2) the development of metabolic engineering tools for each yeast; and (3) demonstrations of metabolic engineering in each yeast. At the end of each section, we provide our assessment, of which yeast is most promising in the near and long term for bioenergy production.

引用

页码：73 / 81

页数：9

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