Management of stage III non-small cell lung cancer

被引：42

作者：

Tabchi, Samer ^{[1
]}

Kassouf, Elie ^{[1
]}

El Rassy, Elie ^{[2
]}

Kourie, Hampig Raphael ^{[3
]}

Martin, Jocelyne ^{[4
]}

Campeau, Marie-Pierre ^{[5
]}

Tehfe, Mustapha ^{[1
]}

Blais, Normand ^{[1
]}

机构：

[1] Ctr Hosp Univ Montreal, Med Oncol Dept, Montreal, PQ, Canada

[2] St Joseph Univ, Fac Med, Hotel Dieu France, Univ Hosp, Beirut, Lebanon

[3] Univ Libre Bruxelles, Jules Bordet Inst, Oncol Dept, Brussels, Belgium

[4] Ctr Hosp Univ Montreal, Dept Thorac Surg, Montreal, PQ, Canada

[5] Ctr Hosp Univ Montreal, Radiat Oncol Dept, Montreal, PQ, Canada

来源：

SEMINARS IN ONCOLOGY | 2017年 / 44卷 / 03期

关键词：

Non-small cell lung cancer; stage III; chemotherapy; radiotherapy; surgery; combined modality; RANDOMIZED PHASE-III; INDIVIDUAL PATIENT DATA; TRANSBRONCHIAL NEEDLE ASPIRATION; POSTOPERATIVE RADIATION-THERAPY; TRIALIST ASSOCIATION ANITA; INDUCTION CHEMOTHERAPY; CONCURRENT CHEMORADIOTHERAPY; CONSOLIDATION CHEMOTHERAPY; THORACIC RADIOTHERAPY; SEQUENTIAL CHEMORADIOTHERAPY;

D O I：

10.1053/j.seminoncol.2017.10.009

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Optimal management of patients with locally advanced non-small cell lung cancer remains challenging in the context of this heterogeneous disease. Despite aggressive therapeutic approaches, survival benefits are still unsatisfactory for what might be viewed as a localized malignancy. A combined modality approach offers patients superior outcomes, especially because technological advances and refined surgical procedures now provide better results with fewer complications. Nevertheless, several features of therapy remain controversial and lack formal prospective data. Traditional cytotoxic chemoradiation therapy may have reached a plateau and future perspectives opting to integrate molecularly targeted agents and immunotherapy might be the way to improve outcomes in this disease subset. (C) 2017 Elsevier Inc. All rights reserved.

引用

页码：163 / 177

页数：15

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