Renal Clearable Gold Nanoparticle-Functionalized Silk Film forin vivoFluorescent Temperature Mapping

被引：5

作者：

Hua, Wei ^{[1
]}

Mao, Yusheng ^{[1
]}

Zhang, Jinzhu ^{[1
]}

Liu, Lang ^{[1
]}

Zhang, Guolin ^{[1
]}

Yang, Shengyang ^{[2
]}

Boyer, Daniel ^{[3
]}

Zhou, Chen ^{[3
]}

Zheng, Fenfen ^{[1
]}

Sun, Shasha ^{[1
]}

Lin, Shengling ^{[1
]}

机构：

[1] Jiangsu Univ Sci & Technol, Sch Environm & Chem Engn, Zhenjiang, Jiangsu, Peoples R China

[2] Yangzhou Univ, Dept Chem & Chem Engn, Yangzhou, Jiangsu, Peoples R China

[3] Univ Cent Missouri, Sch Nat Sci, Warrensburg, MO USA

来源：

FRONTIERS IN CHEMISTRY | 2020年 / 8卷

基金：

中国国家自然科学基金;

关键词：

gold nanoparticles; gold nanoparticles with silk film (AuNPs-SF); temperature sensing; implantable device; fluorescence imaging; NANOCLUSTERS; NANOSENSORS; THERMOMETRY; DEVICES; DOTS;

D O I：

10.3389/fchem.2020.00364

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

Implantable optical sensing devices that can continuously monitor physiological temperature changes hold great potential toward applications in healthcare and medical field. Here, we present a conceptual foundation for the design of biocompatible temperature sensing device by integrating renal clearable luminescent gold nanoparticles (AuNPs) with silk film (AuNPs-SF). We found that the AuNPs display strong temperature dependence in both near-IR fluorescence intensity and lifetime over a large temperature range (10-60 degrees C), with a fluorescence intensity sensitivity of 1.72%/degrees C and lifetime sensitivity of 0.09 mu s/degrees C. When integrated, the AuNPs with biocompatible silk film are implanted in the dorsal region of mice. The fluorescence imaging of the AuNPs-SF in the body shows a linear relationship between the average fluorescence intensity and temperature. More importantly, <3.68% ID gold are left in the body, and no adverse effect is observed for 8 weeks. This AuNPs-SF can be potentially used as a flexible, biocompatible, and implantable sensing device forin vivotemperature mapping.

引用

页数：8