Association of genetic polymorphisms of estrogen and progesterone receptors and endometriosis: Meta-analysis

被引:1
作者
Carneiro, Priscila Prais [1 ]
de Oliveira, Bruna Vicente [1 ]
Teodoro Cordeiro Silva, Antonio Marcio [1 ]
机构
[1] Pontificia Univ Catolica Goias, Dept Med, Escola Ciencias Med Formaceut & Biomed, Av Univ,1069,Setor Univ, BR-74605010 Goiania, Go, Brazil
关键词
Endometriosis; genetic polymorphism; estrogen receptor alpha; estrogen receptor beta; progesterone receptor; BETA-GENE; ALPHA; INFERTILITY; RISK; EPIDEMIOLOGY; PROGINS; T/C;
D O I
10.1177/2284026518819516
中图分类号
R71 [妇产科学];
学科分类号
100211 ;
摘要
Purpose: To investigate the association between polymorphisms in the genes of estrogen receptor alpha, estrogen receptor beta, and progesterone receptor and the genesis of endometriosis. Methods: Systematic review and meta-analysis of articles published fully in the PubMed database, in Portuguese, English, or Spanish, from 2006 to 2017, using the descriptors: "endometriosis," "polymorphism," "ESR1," "ESR2," "PROGINS," "rs9340799," "rs4986938," and "rs1042838." Results: A total of 20 studies were included based on the criterion of search for susceptibility to endometriosis related to polymorphisms of estrogen receptor alpha, estrogen receptor beta, and progesterone receptor genes. Analysis of all polymorphisms found no association with endometriosis. Conclusion: This meta-analysis showed that estrogen receptor alpha, estrogen receptor beta, and progesterone receptor polymorphisms are not related to susceptibility to endometriosis. However, such results may be able to provide more detailed interpretations of how they influence the pathogenesis of endometriosis.
引用
收藏
页码:25 / 36
页数:12
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