HIF-1α is a major and complex player in alcohol induced liver diseases

被引:16
作者
Mehal, Wajahat Z. [1 ]
机构
[1] Yale Univ, Sect Digest Dis, New Haven, CT 06520 USA
关键词
INJURY; ACETAMINOPHEN; FIBROSIS; HYPOXIA; MICE;
D O I
10.1016/j.jhep.2011.09.009
中图分类号
R57 [消化系及腹部疾病];
学科分类号
摘要
引用
收藏
页码:311 / 312
页数:2
相关论文
共 15 条
[1]   Mispairing C57BL/6 Substrains of Genetically Engineered Mice and Wild-Type Controls Can Lead to Confounding Results as It Did in Studies of JNK2 in Acetaminophen and Concanavalin A Liver Injury [J].
Bourdi, Mohammed ;
Davies, John S. ;
Pohl, Lance R. .
CHEMICAL RESEARCH IN TOXICOLOGY, 2011, 24 (06) :794-796
[2]   NLRP6 Inflammasome Regulates Colonic Microbial Ecology and Risk for Colitis [J].
Elinav, Eran ;
Strowig, Till ;
Kau, Andrew L. ;
Henao-Mejia, Jorge ;
Thaiss, Christoph A. ;
Booth, Carmen J. ;
Peaper, David R. ;
Bertin, John ;
Eisenbarth, Stephanie C. ;
Gordon, Jeffrey I. ;
Flavell, Richard A. .
CELL, 2011, 145 (05) :745-757
[3]   Drug-Induced Liver Injury Network (DILIN) Prospective Study Rationale, Design and Conduct [J].
Fontana, Robert J. ;
Watkins, Paul B. ;
Bonkovsky, Herbert L. ;
Chalasani, Naga ;
Davern, Timothy ;
Serrano, Jose ;
Rochon, James .
DRUG SAFETY, 2009, 32 (01) :55-68
[4]   Targeting of HIF-α to the von Hippel-Lindau ubiquitylation complex by O2-regulated prolyl hydroxylation [J].
Jaakkola, P ;
Mole, DR ;
Tian, YM ;
Wilson, MI ;
Gielbert, J ;
Gaskell, SJ ;
von Kriegsheim, A ;
Hebestreit, HF ;
Mukherji, M ;
Schofield, CJ ;
Maxwell, PH ;
Pugh, CW ;
Ratcliffe, PJ .
SCIENCE, 2001, 292 (5516) :468-472
[5]   Alcoholic fatty liver: its pathogenesis and mechanism of progression to inflammation and fibrosis [J].
Lieber, CS .
ALCOHOL, 2004, 34 (01) :9-19
[6]   Reduced liver fibrosis in hypoxia-inducible factor-1α-deficient mice [J].
Moon, Jeon-Ok ;
Welch, Timothy P. ;
Gonzalez, Frank J. ;
Copple, Bryan L. .
AMERICAN JOURNAL OF PHYSIOLOGY-GASTROINTESTINAL AND LIVER PHYSIOLOGY, 2009, 296 (03) :G582-G592
[7]   Deletion of apoptosis signal-regulating kinase 1 attenuates acetaminophen-induced liver injury by inhibiting c-jun N-terminal kinase activation [J].
Nakagawa, Hayato ;
Maeda, Shin ;
Hikiba, Yohko ;
Ohmae, Tomoya ;
Shibata, Wataru ;
Yanai, Ayako ;
Sakamoto, Kei ;
Ogura, Keiji ;
Noguchi, Takuya ;
Karin, Michael ;
Ichijo, Hidenori ;
Omata, Masao .
GASTROENTEROLOGY, 2008, 135 (04) :1311-1321
[8]   Hepatocyte-Specific Hypoxia-Inducible Factor-1α Is a Determinant of Lipid Accumulation and Liver Injury in Alcohol-Induced Steatosis in Mice [J].
Nath, Bharath ;
Levin, Ivan ;
Csak, Timea ;
Petrasek, Jan ;
Mueller, Christian ;
Kodys, Karen ;
Catalano, Donna ;
Mandrekar, Pranoti ;
Szabo, Gyongyi .
HEPATOLOGY, 2011, 53 (05) :1526-1537
[9]   Hypoxia: A Link between Fibrogenesis, Angiogenesis, and Carcinogenesis in Liver Disease [J].
Rosmorduc, Olivier ;
Housset, Chantal .
SEMINARS IN LIVER DISEASE, 2010, 30 (03) :258-270
[10]   INCOMPLETE COMPENSATION OF ENHANCED HEPATIC OXYGEN-CONSUMPTION IN RATS WITH ALCOHOLIC CENTRILOBULAR LIVER NECROSIS [J].
TSUKAMOTO, H ;
XI, XP .
HEPATOLOGY, 1989, 9 (02) :302-306