Determining the role for uric acid in non-alcoholic steatohepatitis development and the utility of urate metabolites in diagnosis: An opinion review

被引:18
作者
Brennan, Paul [1 ]
Clare, Kathleen [2 ]
George, Jacob [1 ]
Dillon, John F. [1 ]
机构
[1] Univ Dundee, Ninewells Hosp & Med Sch, Dept Mol & Clin Med, Kirsty Semple Way, Dundee DD1 9SY, Scotland
[2] Queen Elizabeth Hosp, Dept Neurol, Glasgow G51 4TF, Lanark, Scotland
关键词
Non-alcoholic fatty liver disease; Non-alcoholic steatohepatitis; Uric acid; Urate; Non-invasive fibrosis markers; Fatty liver index; FATTY LIVER-DISEASE; ENDOPLASMIC-RETICULUM STRESS; XANTHINE-OXIDASE; HEPATIC STEATOSIS; POPULATION; PREVALENCE; ACTIVATION; GENERATION; SEVERITY; NONOBESE;
D O I
10.3748/wjg.v26.i15.1683
中图分类号
R57 [消化系及腹部疾病];
学科分类号
摘要
There has long been a recognised association between non-alcoholic fatty liver disease (NAFLD) and the composite aspects of the metabolic syndrome. Part of this association highlighted the supposed co-existence of elevated uric acid levels in those with NAFLD. There is interest in exploitation of this as a putative diagnostic and prognostic biomarker in NAFLD. Given the increased economic and health burden associated with the NAFLD epidemic, improved methods of population-based, minimally-invasive methods and biomarkers are clearly highly sought and necessary. In this opinion review we review the proposed role of uric acid in the pathogenesis of NAFLD and its potential utilisation in the diagnosis and monitoring of the disease process.
引用
收藏
页码:1683 / 1690
页数:8
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