The rs2910164:G>C SNP in the MIR146A Gene is Not Associated with Breast Cancer Risk in BRCA1 and BRCA2 Mutation Carriers

被引：27

作者：

Garcia, Amandine I. ^{[1
]}

Cox, David G. ^{[1
]}

Barjhoux, Laure ^{[1
]}

Verny-Pierre, Carole ^{[1
]}

Barnes, Daniel ^{[2
]}

Antoniou, Antonis C. ^{[2
]}

Stoppa-Lyonnet, Dominique ^{[3
]}

Sinilnikova, Olga M. ^{[1
,4
]}

Mazoyer, Sylvie ^{[1
]}

机构：

[1] Univ Lyon 1, Ctr Leon Berard, Equipe Labellisee LIGUE 2008, CRCL,CNRS,UMR5286,Inserm,U1052, F-69373 Lyon 08, France

[2] Univ Cambridge, Ctr Canc Genet Epidemiol, Dept Publ Hlth & Primary Care, Cambridge, England

[3] Univ Paris 05, Inst Curie, Serv Genet Oncol, INSERM,U830, Paris, France

[4] Ctr Hosp Univ Lyon, Ctr Leon Berard, Unite Mixte Genet Constitut Canc Frequents, Lyon, France

来源：

HUMAN MUTATION | 2011年 / 32卷 / 09期

关键词：

BRCA1; BRCA2; microRNA; SNP; breast cancer; cancer risk; FUNCTIONAL POLYMORPHISM; EXPRESSION; MIR-146A; MICRORNAS; VARIANTS; AGE;

D O I：

10.1002/humu.21539

中图分类号：

Q3 [遗传学];

学科分类号：

071007 ; 090102 ;

摘要：

The rs2910164:G>C SNP is located in the gene for miR-146a, a microRNA that binds the 3' UTR of the BRCA1 transcript. Preliminary data based on the analysis of a small number of cases suggested that this single nucleotide polymorphism (SNP) might be associated with the age of onset of familial breast and ovarian cancer. This effect was not confirmed on a large series of familial breast cancer cases negative for a BRCA1 or BRCA2 mutation. We show here a lack of association of the rs2910164:G>C SNP with breast cancer risk in a series of 1,166 BRCA1 and 560 BRCA2 mutation carriers. In conclusion, the polymorphism in the miR-146a gene is unlikely to be of substantial significance regarding breast cancer risk. Hum Mutat 32:1004-1007, 2011. (C) 2011 Wiley-Liss, Inc.

引用

页码：1004 / 1007

页数：4

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The rs2910164:G&gt;C SNP in the MIR146A Gene is Not Associated with Breast Cancer Risk in BRCA1 and BRCA2 Mutation Carriers

The rs2910164:G>C SNP in the MIR146A Gene is Not Associated with Breast Cancer Risk in BRCA1 and BRCA2 Mutation Carriers