Clinical Outcomes and Immunologic Characteristics of Coronavirus Disease 2019 in People With Human Immunodeficiency Virus

被引：69

作者：

Ho, Hsi-en ^{[1
]}

Peluso, Michael J. ^{[2
]}

Margus, Colton ^{[1
]}

Lopes, Joao Pedro Matias ^{[1
]}

He, Chen ^{[1
]}

Gaisa, Michael M. ^{[1
]}

Osorio, Georgina ^{[1
]}

Aberg, Judith A. ^{[1
]}

Mullen, Michael P. ^{[1
]}

机构：

[1] Icahn Sch Med Mt Sinai, New York, NY 10029 USA

[2] Univ Calif San Francisco, San Francisco, CA 94143 USA

来源：

JOURNAL OF INFECTIOUS DISEASES | 2021年 / 223卷 / 03期

关键词：

HIV; people living with HIV; COVID-19; SARS-CoV-2; coronavirus; inflammation; COVID-19;

D O I：

10.1093/infdis/jiaa380

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

We performed a retrospective study of coronavirus disease 2019 (COVID-19) in people with human immunodeficiency virus (PWH). PWH with COVID-19 demonstrated severe lymphopenia and decreased CD4(+) T cell counts. Levels of inflammatory markers, including C-reactive protein, fibrinogen, D-dimer, interleukin 6, interleukin 8, and tumor necrosis factor alpha were commonly elevated. In all, 19 of 72 hospitalized individuals (26.4%) died and 53 (73.6%) recovered. PWH who died had higher levels of inflammatory markers and more severe lymphopenia than those who recovered. These findings suggest that PWH remain at risk for severe manifestations of COVID-19 despite antiretroviral therapy and that those with increased markers of inflammation and immune dysregulation are at risk for worse outcomes.

引用

页码：403 / 408

页数：6

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