Synthesis and characterization of biodegradable poly (ethylene glycol) and poly (caprolactone diol) end capped poly (propylene fumarate) cross linked amphiphilic hydrogel as tissue engineering scaffold material

被引：15
作者：
Krishna, Lekshmi [1 ]
Jayabalan, Muthu [1 ]
机构：
[1] Sree Chitra Tirunal Inst Med Sci & Technol, Biomed Technol Wing, Div Polymer, Thiruvananthapuram 695012, Kerala, India
来源：
JOURNAL OF MATERIALS SCIENCE-MATERIALS IN MEDICINE | 2009年 / 20卷
关键词：
PROTEIN ADSORPTION; ACRYLAMIDE; RATS; ADHESION;
D O I：
10.1007/s10856-008-3493-3
中图分类号：
R318 [生物医学工程];
学科分类号：
0831 ;
摘要：
Biodegradable poly (caprolactone diol-co-propylene fumarate-co-ethylene glycol) amphiphilic polymer with poly (ethylene glycol) and poly (caprolactone diol) chain ends (PCL-PPF-PEG) was prepared. PCL-PPF-PEG undergoes fast setting with acrylamide (aqueous solution) by free radical polymerization and produces a crosslinked hydrogel. The cross linked and freeze-dried amphiphilic material has porous and interconnected network. It undergoes higher degree of swelling and water absorption to form hydrogel with hydrophilic and hydrophobic domains at the surface and appreciable tensile strength. The present hydrogel is compatible with L929 fibroblast cells. PCL-PPF-PEG/acrylamide hydrogel is a candidate scaffold material for tissue engineering applications.
引用
收藏
页码：115 / 122
页数：8
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