Investigations into the immunomodulatory activity of Argyreia speciosa

被引：79

作者：

Gokhale, AB ^{[1
]}

Damre, AS ^{[1
]}

Saraf, MN ^{[1
]}

机构：

[1] Bombay Coll Pharm, Dept Pharmacol, Bombay 400098, Maharashtra, India

来源：

JOURNAL OF ETHNOPHARMACOLOGY | 2003年 / 84卷 / 01期

关键词：

Argyreia speciosa; immunomodulation; cell-mediated immunity; humoral immunity; phagocytosis;

D O I：

10.1016/S0378-8741(02)00168-X

中图分类号：

Q94 [植物学];

学科分类号：

071001 ;

摘要：

The objective of the present study was to investigate the immunomodulatory activity of Argyreia speciosa on cellular and humoral immunity. Oral administration of the ethanolic extract of A. speciosa root (ASEE), at the doses of 50, 100 and 200 mg/kg in mice, dose-dependently potentiated the delayed-type hypersensitivity reaction induced both by sheep red blood cells (SRBC) and oxazolone. It significantly enhanced the production of circulating antibody titre in mice in response to SRBC. ASEE failed to show any effect on macrophage phagocytosis. Chronic administration of ASEE significantly ameliorated the total white blood cell count and also restored the myelosuppressive effects induced by cyclophosphamide. The present investigation reveals that ASEE possesses immunomodulatory activity. (C) 2002 Elsevier Science Ireland Ltd. All rights reserved.

引用

页码：109 / 114

页数：6

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