Maintaining imprinting

被引：7

作者：

Mann, MRW ^{[1
]}

Bartolomei, MS

机构：

[1] Univ Penn, Sch Med, Howard Hughes Med Inst, Philadelphia, PA 19104 USA

[2] Univ Penn, Sch Med, Dept Cell & Dev Biol, Philadelphia, PA 19104 USA

来源：

NATURE GENETICS | 2000年 / 25卷 / 01期

关键词：

D O I：

10.1038/75575

中图分类号：

Q3 [遗传学];

学科分类号：

071007 ; 090102 ;

摘要：

The imprinting of a large cluster of paternally expressed genes at the Prader-Willi syndrome locus is established by an imprinting centre in human and mouse. Deletions carried by a member of a rare family and by chimaeric mice demonstrate that the imprinting centre is additionally required for postzygotic maintenance of paternal identity.

引用

页码：4 / 5

页数：2

共 10 条

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