Maintaining imprinting

被引：7
作者：
Mann, MRW [1 ]
Bartolomei, MS
机构：
[1] Univ Penn, Sch Med, Howard Hughes Med Inst, Philadelphia, PA 19104 USA
[2] Univ Penn, Sch Med, Dept Cell & Dev Biol, Philadelphia, PA 19104 USA
来源：
NATURE GENETICS | 2000年 / 25卷 / 01期
关键词：
D O I：
10.1038/75575
中图分类号：
Q3 [遗传学];
学科分类号：
071007 ; 090102 ;
摘要：
The imprinting of a large cluster of paternally expressed genes at the Prader-Willi syndrome locus is established by an imprinting centre in human and mouse. Deletions carried by a member of a rare family and by chimaeric mice demonstrate that the imprinting centre is additionally required for postzygotic maintenance of paternal identity.
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页码：4 / 5
页数：2
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