NGF Is Essential for Hippocampal Plasticity and Learning

被引：163

作者：

Conner, James M. ^{[1
]}

Franks, Kevin M. ^{[2
,3
]}

Titterness, Andrea K. ^{[6
]}

Russell, Kyle ^{[6
]}

Merrill, David A. ^{[1
]}

Christie, Brian R. ^{[6
,7
]}

Sejnowski, Terrence J. ^{[2
,3
,5
]}

Tuszynski, Mark H. ^{[1
,4
]}

机构：

[1] Univ Calif San Diego, Dept Neurosci, La Jolla, CA 92093 USA

[2] Univ Calif San Diego, Dept Biol, La Jolla, CA 92093 USA

[3] Salk Inst Biol Studies, Computat Neurobiol Lab, La Jolla, CA 92037 USA

[4] Vet Adm Med Ctr, San Diego, CA 92161 USA

[5] Howard Hughes Med Inst, San Diego, CA 92161 USA

[6] Univ British Columbia, Neurosci Program, Vancouver, BC V6T 1Z4, Canada

[7] Univ Victoria, Div Med Sci, Victoria, BC V8W 2Y2, Canada

来源：

JOURNAL OF NEUROSCIENCE | 2009年 / 29卷 / 35期

基金：

加拿大健康研究院; 美国国家卫生研究院;

关键词：

NERVE GROWTH-FACTOR; LONG-TERM POTENTIATION; MUSCARINIC RECEPTOR ACTIVATION; FOREBRAIN CHOLINERGIC NEURONS; DEPENDENT SYNAPTIC PLASTICITY; BASAL FOREBRAIN; CONTINUOUS-INFUSION; MEMORY IMPAIRMENT; FACTOR INCREASES; GENE-EXPRESSION;

D O I：

10.1523/JNEUROSCI.2594-09.2009

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

Nerve growth factor (NGF) is produced in the hippocampus throughout life and is retrogradely trafficked to septal cholinergic neurons, providing a potential mechanism for modulating cholinergic inputs and, thereby, hippocampal plasticity. To explore NGF modulation of hippocampal plasticity and function, NGF levels were augmented or blocked in intact adult rats, and subsequent in vivo effects on cholinergic neurons, hippocampal long-term potentiation (LTP), and learning were examined. NGF augmentation significantly enhanced cholinergic neuronal markers and facilitated induction of hippocampal LTP. Blockade of endogenous NGF significantly reduced hippocampal LTP and impaired retention of spatial memory. These findings reveal an essential role for NGF in regulating biological mechanisms related to plasticity and memory in the intact adult brain.

引用

页码：10883 / 10889

页数：7

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