Emerging clinical concerns in the ageing haemophilia patient

被引：49

作者：

Konkle, B. A. ^{[1
]}

Kessler, C. ^{[2
]}

Aledort, L. ^{[3
]}

Andersen, J. ^{[4
]}

Fogarty, P. ^{[5
]}

Kouides, P. ^{[6
]}

Quon, D. ^{[7
]}

Ragni, M. ^{[8
,9
]}

Zakarija, A. ^{[10
]}

Ewenstein, B. ^{[11
]}

机构：

[1] Univ Penn, Sch Med, Penn Comprehens Hemophilia Program, Philadelphia, PA 19104 USA

[2] Georgetown Univ Hosp, Lombardi Canc Ctr, Washington, DC 20007 USA

[3] Mt Sinai Sch Med, New York, NY USA

[4] DMC Karmanos Canc Inst, Comprehens Ctr Bleeding Disorders & Thrombosis, Detroit, MI USA

[5] Univ Calif San Francisco, San Francisco, CA 94143 USA

[6] Mary M Gooley Hemophilia Ctr, Rochester, NY USA

[7] Orthopaed Hosp Los Angeles, Hemophilia Treatment Ctr, Los Angeles, CA USA

[8] Univ Pittsburgh, Med Ctr, Pittsburgh, PA USA

[9] Hemophilia Ctr Western Penn, Pittsburgh, PA USA

[10] Northwestern Univ, Div Hematol Oncol, Chicago, IL 60611 USA

[11] Baxter Healthcare Corp, Westlake Village, CA USA

来源：

HAEMOPHILIA | 2009年 / 15卷 / 06期

关键词：

ageing; comorbidities; haemophilia; CHRONIC HEPATITIS-C; IMMUNODEFICIENCY-VIRUS INFECTION; ISCHEMIC-HEART-DISEASE; HIV-POSITIVE PATIENTS; STAGE LIVER-DISEASE; HEPATOCELLULAR-CARCINOMA; METABOLIC SYNDROME; FACTOR-VIII; ARTHROSCOPIC SYNOVECTOMY; ANTIRETROVIRAL THERAPY;

D O I：

10.1111/j.1365-2516.2009.02066.x

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

The availability of safe replacement clotting factor concentrates together with effective antiviral drugs to treat human immunodeficiency and hepatitis C viruses and the provision of care at designated haemophilia treatment centres have resulted in a new phenomenon in haemophilia management - the ageing patient. Today, increasing numbers of persons with haemophilia (PWH) are middle-aged and older, and they face the same age-related health issues as the general population. The impact of these risks on PWH is unclear, however, and there is a paucity of information about how to manage comorbidities in this patient population. This review focuses on five comorbidities that uniquely affect older PWH: cardiovascular disease, liver disease, cancer, renal disease and joint disease. Available research is summarized and potential management approaches are suggested.

引用

页码：1197 / 1209

页数：13

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