Reduced burden of diabetes and improved quality of life: Experiences from unrestricted day-and-night hybrid closed-loop use in very young children with type 1 diabetes

被引：89

作者：

Musolino, Gianluca ^{[1
]}

Dovc, Klemen ^{[2
]}

Boughton, Charlotte K. ^{[1
]}

Tauschmann, Martin ^{[1
,3
,4
]}

Allen, Janet M. ^{[1
,3
]}

Nagl, Katrin ^{[4
]}

Fritsch, Maria ^{[4
]}

Yong, James ^{[5
]}

Metcalfe, Emily ^{[5
]}

Schaeffer, Dominique ^{[6
]}

Fichelle, Muriel ^{[6
]}

Schierloh, Ulrike ^{[6
]}

Thiele, Alena G. ^{[7
]}

Abt, Daniela ^{[8
]}

Kojzar, Harald ^{[9
]}

Mader, Julia K. ^{[9
]}

Slegtenhorst, Sonja ^{[10
]}

Ashcroft, Nicole ^{[1
]}

Wilinska, Malgorzata E. ^{[1
,3
]}

Sibayan, Judy ^{[11
]}

Cohen, Nathan ^{[11
]}

Kollman, Craig ^{[11
]}

Hofer, Sabine E. ^{[8
]}

Froehlich-Reiterer, Elke ^{[12
]}

Kapellen, Thomas M. ^{[7
]}

Acerini, Carlo L. ^{[3
]}

de Beaufort, Carine ^{[6
,13
]}

Campbell, Fiona ^{[5
]}

Rami-Merhar, Birgit ^{[4
]}

Hovorka, Roman ^{[1
,3
]}

机构：

[1] Univ Cambridge, Wellcome Trust M RC Inst Metab Sci, Cambridge, England

[2] Univ Med Ctr, Dept Paediat Endocrinol Diabet & Metab Dis, Univ Childrens Hosp, Ljubljana, Slovenia

[3] Univ Cambridge, Dept Paediat, Cambridge, England

[4] Med Univ Vienna, Dept Pediat & Adolescent Med, Vienna, Austria

[5] Leeds Childrens Hosp, Dept Paediat Diabet, Leeds, W Yorkshire, England

[6] Ctr Hosp, Dept Pediat Diabet & Endocrinol, Clin Pediat, Luxembourg, Luxembourg

[7] Univ Leipzig, Div Paediat Diabetol, Leipzig, Germany

[8] Med Univ Innsbruck, Dept Pediat 1, Innsbruck, Austria

[9] Med Univ Graz, Dept Internal Med, Div Endocrinol & Diabetol, Graz, Austria

[10] Cambridge Univ Hosp NHS Fdn Trust, Dept Nutr & Dietet, Cambridge, England

[11] Jaeb Ctr Hlth Res, Tampa, FL USA

[12] Med Univ Graz, Dept Pediat & Adolescent Med, Graz, Austria

[13] Free Univ VUB, Dept Pediat, Brussels, Belgium

来源：

PEDIATRIC DIABETES | 2019年 / 20卷 / 06期

基金：

英国惠康基金;

关键词：

artificial pancreas; closed-loop insulin delivery; type; 1; diabetes; very young children; HYPOGLYCEMIA; PARENTS;

D O I：

10.1111/pedi.12872

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Objective To evaluate the experiences of families with very young children aged 1 to 7 years (inclusive) with type 1 diabetes using day-and-night hybrid closed-loop insulin delivery. Methods Parents/caregivers of 20 children aged 1 to 7 years with type 1 diabetes completed a closed-loop experience survey following two 3-week periods of unrestricted day-and-night hybrid closed-loop insulin therapy using Cambridge FlorenceM system at home. Benefits, limitations, and improvements of closed-loop technology were explored. Results Responders reported reduced burden of diabetes management, less time spent managing diabetes, and improved quality of sleep with closed-loop. Ninety percent of the responders felt less worried about their child's glucose control using closed-loop. Size of study devices, battery performance and connectivity issues were identified as areas for improvement. Parents/caregivers wished for more options to input information to the system such as temporary glucose targets. Conclusions Parents/caregivers of very young children reported important quality of life benefits associated with using closed-loop, supporting adoption of this technology in this population.

引用

页码：794 / 799

页数：6

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