Undifferentiated Primary Carcinoma of the Epididymis Treated with Sequential Chemoradiotherapy: A Case Report

Primary epididymal adenocarcinoma is uncommon, and undifferentiated histology is exceedingly rare. Surgery is the principle treatment for primary epididymal tumors. Benign tumors are commonly managed by transscrotal epididymectomy, however, inguinal radical orchiectomy is indicated for malignant tumors of epididymis including the primary epididymal carcinomas (PEC). However, the adjuvant treatment of PEC is more complex and there exists no generally accepted consensus on this issue. Carboplatin and paclitaxel combination is the commonly preferred first-line CT regimen in metastatic epididymal tumors, however no specific chemotherapy (CT) regimen has been recommended for adjuvant management of PECs. Similarly, there are uncertainties regarding the role of adjuvant radiation therapy (RT) in this small group of patients, and to our literature knowledge only five PECs have previously been treated with adjuvant RT in a curative intent. To add to the present literature, we report a further case of undifferentiated primary epididymal carcinoma and its clinical course, in a 54-year-old male treated with adjuvant chemotherapy and radiotherapy.