Synthesis and structure-activity relationship of C-3 benzoyloxymethyl cephalosporins exhibiting anti-MRSA activities

被引：13

作者：

Kim, OK ^{[1
]}

Ueda, Y ^{[1
]}

Mansuri, MM ^{[1
]}

Russell, JW ^{[1
]}

Bidwell, VW ^{[1
]}

机构：

[1] BRISTOL MYERS SQUIBB CO,PHARMACEUT RES INST,METAB & PHARMACOKINET,WALLINGFORD,CT 06492

来源：

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS | 1997年 / 7卷 / 14期

关键词：

D O I：

10.1016/S0960-894X(97)00338-7

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

A series of cephalosporins bearing C-3 benzoyloxymethyl groups were prepared and evaluated for their anti-MRSA activity and plasma stability. They exhibit excellent in vitro activity (MIC = 0.06 similar to 2 mu g/mL) against MRSA and excellent stability in human plasma. (C) 1997 Elsevier Science Ltd.

引用

页码：1945 / 1950

页数：6

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