Interleukin-17 expression in the human placenta

被引：49

作者：

Pongcharoen, S.

Somran, J.

Sritippayawan, S.

Niumsup, P.

Chanchan, P.

Butkhamchot, P.

Tatiwat, P.

Kunngurn, S.

Searle, R. F.

机构：

[1] Newcastle Univ, Sch Med, Anat & Clin Skills Ctr, Newcastle Upon Tyne NE2 4HH, Tyne & Wear, England

[2] Naresuan Univ, Dept Med, Phitsanulok, Thailand

[3] Naresuan Univ, Dept Pathol & Forens Med, Phitsanulok, Thailand

[4] Naresuan Univ, Fac Med, Phitsanulok, Thailand

[5] Naresuan Univ, Fac Med Sci, Dept Microbiol & Parasitol, Phitsanulok, Thailand

[6] Buddachinaraj Hosp, Dept Anat Pathol, Phitsanulok, Thailand

来源：

PLACENTA | 2007年 / 28卷 / 01期

关键词：

human; IL-17; mRNA; expression; placenta;

D O I：

10.1016/j.placenta.2006.01.016

中图分类号：

Q [生物科学];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

Interleukin (IL)-17 is a proinflammatory cytokine with pleiotropic activities including inducing neovascularization and production of proangiogenic molecules. As pregnancy outcome depends on the balance of Th1-like/Th2-like cytokines and an increased blood supply to the feto-placental unit, the expression of IL-17 mRNA and protein in human placental tissues was investigated. IL-17 mRNA was expressed by purified cytokeratin-positive term placental trophoblast cells, HLA-G+ extravillous trophoblast cells and placental macrophages (Hofbauer cells). IL-17 localized in both cyto- and syncytiotrophoblasts of normal term pregnancy, spontaneous miscarriage and in molar pregnancy. In spontaneous miscarriage and molar pregnancy extravillous trophoblast cells were consistently immunoreactive for IL-17. IL-17 expression in human placenta may play a key role in angiogenesis and/or immunoregulation in the establishment of pregnancy. (c) 2006 Elsevier Ltd. All rights reserved.

引用

页码：59 / 63

页数：5

共 25 条

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