Fecal Microbiota Transplant Protocol for Clostridium Difficile Infection

被引:20
作者
Tauxe, William M. [1 ]
Dhere, Tanvi [2 ]
Ward, Angela [2 ]
Racsa, Lori D. [3 ]
Varkey, Jay B. [4 ]
Kraft, Colleen S. [3 ,4 ]
机构
[1] Emory Univ, Sch Med, Atlanta, GA 30322 USA
[2] Emory Univ, Sch Med, Div Digest Dis, Atlanta, GA USA
[3] Emory Univ, Sch Med, Dept Pathol & Lab Med, Atlanta, GA 30322 USA
[4] Emory Univ, Sch Med, Div Infect Dis, Atlanta, GA USA
来源
LABMEDICINE | 2015年 / 46卷 / 01期
关键词
FMT; fecal microbiota transplant; Clostridium difficile; CDI; stool;
D O I
10.1309/LMCI95M0TWPDZKOD
中图分类号
R446 [实验室诊断]; R-33 [实验医学、医学实验];
学科分类号
1001 ;
摘要
Fecal microbiota transplant has become more acceptable as a therapeutic for recurrent Clostridium difficile infection. The FDA has an enforcement discretion policy for practitioner's performing this therapy, which includes informed consent for this experimental treatment. This manuscript describes a typical procedure that can be followed that includes the important aspects of this preparation and treatment.
引用
收藏
页码:E19 / E23
页数:5
相关论文
共 5 条
[1]   Recurrent Clostridium difficile colitis:: Case series involving 18 patients treated with donor stool administered via a nasogastric tube [J].
Aas, J ;
Gessert, CE ;
Bakken, JS .
CLINICAL INFECTIOUS DISEASES, 2003, 36 (05) :580-585
[2]   Fecal Microbiota Transplantation for Relapsing Clostridium difficile Infection in 26 Patients Methodology and Results [J].
Kelly, Colleen R. ;
de Leon, Lauren ;
Jasutkar, Niren .
JOURNAL OF CLINICAL GASTROENTEROLOGY, 2012, 46 (02) :145-149
[3]   Targeted Restoration of the Intestinal Microbiota with a Simple, Defined Bacteriotherapy Resolves Relapsing Clostridium difficile Disease in Mice [J].
Lawley, Trevor D. ;
Clare, Simon ;
Walker, Alan W. ;
Stares, Mark D. ;
Connor, Thomas R. ;
Raisen, Claire ;
Goulding, David ;
Rad, Roland ;
Schreiber, Fernanda ;
Brandt, Cordelia ;
Deakin, Laura J. ;
Pickard, Derek J. ;
Duncan, Sylvia H. ;
Flint, Harry J. ;
Clark, Taane G. ;
Parkhill, Julian ;
Dougan, Gordon .
PLOS PATHOGENS, 2012, 8 (10)
[4]  
United States Government DoHaHS, 2013, GUID IND ENF POL REG
[5]  
van Nood E, 2013, NEW ENGL J MED, V368, P2145, DOI [10.1056/NEJMoa1205037, 10.1056/NEJMc1303919]