Elevated Plasma Soluble C-Type Lectin-like Receptor 2 Is Associated with the Worsening of Coronavirus Disease 2019

被引:22
作者
Wada, Hideo [1 ]
Ichikawa, Yuhuko [2 ]
Ezaki, Minoru [2 ]
Yamamoto, Akitaka [3 ]
Tomida, Masaki [3 ]
Yoshida, Masamichi [4 ]
Fukui, Shunsuke [5 ]
Moritani, Isao [5 ]
Shiraki, Katsuya [1 ]
Shimaoka, Motomu [6 ]
Iba, Toshiaki [7 ]
Suzuki-Inoue, Katsue [8 ]
Shimpo, Hideto [9 ]
机构
[1] Mie Prefectural Gen Med Ctr, Dept Gen & Lab Med, Yokaichi 5100885, Japan
[2] Mie Prefectural Gen Med Ctr, Dept Cent Lab, Yokaichi 5100885, Japan
[3] Mie Prefectural Gen Med Ctr, Dept Emergency & Crit Care Ctr, Yokaichi 5100885, Japan
[4] Mie Prefectural Gen Med Ctr, Dept Resp Med, Yokaichi 5100885, Japan
[5] Mie Prefectural Gen Med Ctr, Dept Gastroenterol, Yokaichi 5100885, Japan
[6] Mie Univ, Dept Mol Pathobiol & Cell Adhes Biol, Grad Sch Med, Tsu, Mie 5148507, Japan
[7] Juntendo Univ, Dept Emergency & Disaster Med, Grad Sch Med, Tokyo 1138421, Japan
[8] Univ Yamanashi, Dept Clin & Lab Med, Fac Med, Yamanashi 4093898, Japan
[9] Mie Prefectural Gen Med Ctr, Yokaichi 5100885, Japan
关键词
COVID-19; coagulopathy; platelet activation; sCLEC-2; THROMBOTIC COMPLICATIONS; COVID-19; ACTIVATION; MECHANISMS; PLATELET;
D O I
10.3390/jcm11040985
中图分类号
R5 [内科学];
学科分类号
1002 ; 100201 ;
摘要
Although thrombosis in coronavirus disease 2019 (COVID-19) infection has attracted attention, the mechanism underlying its development remains unclear. The relationship between platelet activation and the severity of COVID-19 infection was compared with that involving other infections. Plasma soluble C-type lectin-like receptor 2 (sCLEC-2) levels were measured in 46 patients with COVID-19 infection and in 127 patients with other infections. The plasma sCLEC-2 levels in patients with COVID-19 infection {median (25th, 75th percentile), 489 (355, 668) ng/L} were significantly higher (p < 0.001) in comparison to patients suffering from other pneumonia {276 (183, 459) ng/L}, and the plasma sCLEC-2 levels of COVID-19 patients with severe {641 (406, 781) ng/L} or critical illness {776 (627, 860) ng/L} were significantly higher (p < 0.01, respectively) in comparison to those with mild illness {375 (278, 484) ng/L}. The ratio of the sCLEC-2 levels to platelets in COVID-19 patients with critical illness of infection was significantly higher (p < 0.01, p < 0.001 and p < 0.05, respectively) in comparison to COVID-19 patients with mild, moderate or severe illness. Plasma sCLEC-2 levels were significantly higher in patients with COVID-19 infection than in those with other infections, suggesting that platelet activation is triggered and facilitated by COVID-19 infection.
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页数:9
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