Regulation of transcription in cancer

被引：4
作者：
Trzyna, Elzbieta [1 ]
Duleba, Marcin [1 ]
Faryna, Marta [1 ]
Majka, Marcin [1 ]
机构：
[1] Jagiellonian Univ, Sch Med, Polish Amer Inst Pediat, Dept Transplantat, Krakow, Poland
来源：
FRONTIERS IN BIOSCIENCE-LANDMARK | 2012年 / 17卷
关键词：
Promoter; Transcription; Gene Regulation; Polymorphism; Cancer; DNA methylation; Review; SINGLE NUCLEOTIDE POLYMORPHISM; HEPATOCYTE GROWTH-FACTOR; C-MET EXPRESSION; METALLOPROTEINASE-1 PROMOTER POLYMORPHISM; II CORE PROMOTER; DNA METHYLATION; MATRIX METALLOPROTEINASE-1; GENE PROMOTER; E-CADHERIN; INVASIVE GROWTH;
D O I：
10.2741/3929
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
The purpose of this article is to provide an overview on the regulation of transcription in cancer cells. We describe here standard mechanisms of transcription in eukaryotic cells, an influence of common promoter polymorphisms contributing to malignant progression and DNA methylation as significant aspect of gene regulation. We also described transcription factors mechanism of action, and how their alteration can result in cancer.
引用
收藏
页码：316 / 330
页数：15
相关论文
共 97 条
  • [1] Regulation of c-Met-dependent gene expression by PTEN
    Abounader, R
    Reznik, T
    Colantuoni, C
    Martinez-Murillo, F
    Rosen, EM
    Laterra, J
    [J]. ONCOGENE, 2004, 23 (57) : 9173 - 9182
  • [2] A novel promoter-tethering element regulates enhancerdriven gene expression at the bithorax complex in the Drosophila embryo
    Akbari, Omar S.
    Bae, Esther
    Johnsen, Holly
    Villaluz, Alfred
    Wong, Debbie
    Drewell, Robert A.
    [J]. DEVELOPMENT, 2008, 135 (01): : 123 - 131
  • [3] MDM2 promoter polymorphism and pancreatic cancer risk and prognosis
    Asomaning, Kofi
    Reid, Amy E.
    Zhou, Wei
    Heist, Rebecca S.
    Zhai, Rihong
    Su, Li
    Kwak, Eunice L.
    Blaszkowsky, Lawrence
    Zhu, Andrew X.
    Ryan, David P.
    Christiani, David C.
    Liu, Geoffrey
    [J]. CLINICAL CANCER RESEARCH, 2008, 14 (12) : 4010 - 4015
  • [4] The AA genotype of the regulatory BCL2 promoter polymorphism (-938C⟩A) is associated with a favorable outcome in lymph node-negative invasive breast cancer patients
    Bachmann, Hagen S.
    Otterbach, Friedrich
    Callies, Rainer
    Nueckel, Holger
    Bau, Maja
    Schmid, Kurt W.
    Siffert, Winfried
    Kimmig, Rainer
    [J]. CLINICAL CANCER RESEARCH, 2007, 13 (19) : 5790 - 5797
  • [5] Endometrial cancer risk is associated with variants of the mismatch repair genes MLH1 and MSH2
    Beiner, Mario E.
    Rosen, Barry
    Fyles, Anthony
    Harley, Ian
    Pal, Tuya
    Siminovitch, Kathy
    Zhang, Shiyu
    Sun, Ping
    Narod, Steven A.
    [J]. CANCER EPIDEMIOLOGY BIOMARKERS & PREVENTION, 2006, 15 (09) : 1636 - 1640
  • [6] The DNA methyltransferases of mammals
    Bestor, TH
    [J]. HUMAN MOLECULAR GENETICS, 2000, 9 (16) : 2395 - 2402
  • [7] Bestor TH, 1998, CIBA F SYMP, V214, P187
  • [8] Bestor TH, 1998, NOVART FDN SYMP, V214, P228
  • [9] Up-regulation of MET expression by α-melanocyte-stimulating hormone and MITF allows hepatocyte growth factor to protect melanocytes and melanoma cells from apoptosis
    Beuret, Laurent
    Flori, Enrica
    Denoyelle, Christophe
    Bille, Karine
    Busca, Roser
    Picardo, Mauro
    Bertolotto, Corine
    Ballotti, Robert
    [J]. JOURNAL OF BIOLOGICAL CHEMISTRY, 2007, 282 (19) : 14140 - 14147
  • [10] DNA methylation patterns and epigenetic memory
    Bird, A
    [J]. GENES & DEVELOPMENT, 2002, 16 (01) : 6 - 21
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