The mechanisms tumor cells utilize to evade the host's immune system

被引：49
作者：
Kuol, Nyanbol [1 ]
Stojanovska, Lily [1 ]
Nurgali, Kulmira [1 ]
Apostolopoulos, Vasso [1 ]
机构：
[1] Victoria Univ, Coll Hlth & Biomed, Ctr Chron Dis, POB 14426, Melbourne, Vic 8001, Australia
来源：
MATURITAS | 2017年 / 105卷
关键词：
Programmed death-ligand 1; Indoleamine-2,3-dioxygenase; Siglec-9; Major histocompatibility complex; Tumor escape; MHC CLASS-I; BREAST-CANCER CELLS; REGULATORY T-CELLS; PD-L1; EXPRESSION; SUPPRESSOR-CELLS; POOR-PROGNOSIS; INFILTRATING LYMPHOCYTES; COLORECTAL-CANCER; DOWN-REGULATION; GROWTH-FACTOR;
D O I：
10.1016/j.maturitas.2017.04.014
中图分类号：
R592 [老年病学]; C [社会科学总论];
学科分类号：
03 ; 0303 ; 100203 ;
摘要：
The immune system plays an essential role in the tumor progression; not only can it inhibit tumor growth but it can also promote tumor growth by establishing a favorable environment. Tumor cells utilize several strategies to evade the hoses immune system, including expression of immunosuppressive molecules such as PD-L1, IDO and siglec-9. In addition, tumor cells not only regulate the recruitment and development of immunosuppressive forces to influence the tumor microenvironment but also shift the phenotype and function of normal immune cells from a possibly anti-tumor state to a pro-tumor state. As a result, tumor cells evade the hoses immune system, leading to metastasis and/or recurrent disease.
引用
收藏
页码：8 / 15
页数：8
相关论文
共 142 条
[31]   Foxp3 Programs the Development and Function of CD4+CD25+ Regulatory T Cells (Reprinted from vol 4, pg 330-336, 2003) [J].
Fontenot, Jason D. ;
Gavin, Marc A. ;
Rudensky, Alexander Y. .
JOURNAL OF IMMUNOLOGY, 2017, 198 (03) :986-992
[32]   PD-L1 regulates the development, maintenance, and function of induced regulatory T cells [J].
Francisco, Loise M. ;
Salinas, Victor H. ;
Brown, Keturah E. ;
Vanguri, Vijay K. ;
Freeman, Gordon J. ;
Kuchroo, Vijay K. ;
Sharpe, Arlene H. .
JOURNAL OF EXPERIMENTAL MEDICINE, 2009, 206 (13) :3015-3029
[33]   Polarization of Tumor-Associated Neutrophil Phenotype by TGF-β: "N1" versus "N2" TAN [J].
Fridlender, Zvi G. ;
Sun, Jing ;
Kim, Samuel ;
Kapoor, Veena ;
Cheng, Guanjun ;
Ling, Leona ;
Worthen, G. Scott ;
Albelda, Steven M. .
CANCER CELL, 2009, 16 (03) :183-194
[34]   Tryptophan-derived catabolites are responsible for inhibition of T and natural killer cell proliferation induced by indoleamine 2,3-dioxygenase [J].
Frumento, G ;
Rotondo, R ;
Tonetti, M ;
Damonte, G ;
Benatti, U ;
Ferrara, GB .
JOURNAL OF EXPERIMENTAL MEDICINE, 2002, 196 (04) :459-468
[35]   Coordinated regulation of myeloid cells by tumours [J].
Gabrilovich, Dmitry I. ;
Ostrand-Rosenberg, Suzanne ;
Bronte, Vincenzo .
NATURE REVIEWS IMMUNOLOGY, 2012, 12 (04) :253-268
[36]   Myeloid-derived suppressor cells as regulators of the immune system [J].
Gabrilovich, Dmitry I. ;
Nagaraj, Srinivas .
NATURE REVIEWS IMMUNOLOGY, 2009, 9 (03) :162-174
[37]   Occurrence and significance of tumor-associated neutrophils in patients with colorectal cancer [J].
Galdiero, Maria Rosaria ;
Bianchi, Paolo ;
Grizzi, Fabio ;
Di Caro, Giuseppe ;
Basso, Gianluca ;
Ponzetta, Andrea ;
Bonavita, Eduardo ;
Barbagallo, Marialuisa ;
Tartari, Silvia ;
Polentarutti, Nadia ;
Malesci, Alberto ;
Marone, Gianni ;
Roncalli, Massimo ;
Laghi, Luigi ;
Garlanda, Cecilia ;
Mantovani, Alberto ;
Jaillon, Sebastien .
INTERNATIONAL JOURNAL OF CANCER, 2016, 139 (02) :446-456
[38]   MHC class I antigens, immune surveillance, and tumor immune escape [J].
Garcia-Lora, A ;
Algarra, I ;
Garrido, F .
JOURNAL OF CELLULAR PHYSIOLOGY, 2003, 195 (03) :346-355
[39]   Neutrophils drive accelerated tumor progression in the collagen-dense mammary tumor microenvironment [J].
Garcia-Mendoza, Maria G. ;
Inman, David R. ;
Ponik, Suzanne M. ;
Jeffery, Justin J. ;
Sheerar, Dagna S. ;
Van Doorn, Rachel R. ;
Keely, Patricia J. .
BREAST CANCER RESEARCH, 2016, 18
[40]   FOXP3+ Tregs and B7-HI+/PD-I+T lymphocytes co-infiltrate the tumor tissues of high-risk breast cancer patients:: Implication for immunotherapy [J].
Ghebeh, Hazem ;
Barhoush, Eman ;
Tulbah, Asma ;
Elkum, Naser ;
Al-Tweigeri, Taher ;
Dermime, Said .
BMC CANCER, 2008, 8 (1)
12345678910