A historical perspective on the role of stroma in the pathogenesis of benign prostatic hyperplasia

被引：27

作者：

Cunha, Gerald R. ^{[1
]}

Ricke, William A. ^{[2
]}

机构：

[1] Univ Calif San Francisco, Dept Urol, San Francisco, CA 94143 USA

[2] UWCCC, Dept Urol, Madison, WI 53705 USA

来源：

DIFFERENTIATION | 2011年 / 82卷 / 4-5期

关键词：

Prostate; Benign prostatic hyperplasia; Mesenchymal-epithelial interactions; UROGENITAL SINUS MESENCHYME; SEMINAL-VESICLE MESENCHYME; TISSUE RECOMBINANTS; EPITHELIAL INTERACTIONS; URINARY-BLADDER; INSTRUCTIVE INDUCTION; PARACRINE REGULATION; STEROID-HORMONES; MOUSE UTERUS; CELL-LINE;

D O I：

10.1016/j.diff.2011.04.002

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

This review summarizes the concept that the neo-formation of ductal-acinar architecture in the pathogenesis of benign prostatic hyperplasia (BPH) is due to the reactivation of embryonic inductive activity by BPH stroma, an idea enunciated by John McNeal. The concept is the synthesis of McNeal's astute pathological inference based upon developmental biology and supported by the mesenchymal-epithelial interaction studies. In a broader context, McNeal's concept of framing epithelial pathogenesis in terms of developmental biological principals has been extended more recently into the field of carcinogenesis under the umbrella of tumor microenvironment. (C) 2011 International Society of Differentiation. Published by Elsevier B.V. All rights reserved.

引用

页码：168 / 172

页数：5

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