Gut Bacteria Erysipelatoclostridium and Its Related Metabolite Ptilosteroid A Could Predict Radiation-Induced Intestinal Injury

被引：24

作者：

Cai, Shang ^{[1
,2
,3
]}

Yang, Yongqiang ^{[1
,2
,3
]}

Kong, Yuehong ^{[1
,2
,3
]}

Guo, Qi ^{[1
,2
,3
]}

Xu, Yingying ^{[1
,2
,3
]}

Xing, Pengfei ^{[1
,2
,3
]}

Sun, Yanze ^{[1
,2
,3
]}

Qian, Jianjun ^{[1
,2
,3
]}

Xu, Ruizhe ^{[1
,2
,3
]}

Xie, Liwei ^{[1
,2
,3
]}

Hu, Yijia ^{[1
,2
,3
]}

Wang, Min ^{[4
]}

Li, Ming ^{[5
]}

Tian, Ye ^{[1
,2
,3
]}

Mao, Weidong ^{[1
,2
,3
]}

机构：

[1] Soochow Univ, Affiliated Hosp 2, Dept Radiotherapy & Oncol, Suzhou, Peoples R China

[2] Soochow Univ, Inst Radiotherapy & Oncol, Suzhou, Peoples R China

[3] Suzhou Key Lab Radiat Oncol, Suzhou, Peoples R China

[4] Soochow Univ, Affiliated Hosp 2, Dept Clin Lab, Suzhou, Peoples R China

[5] Soochow Univ, Collaborat Innovat Ctr Radiat Med Jiangsu Higher, Sch Radiat Med & Protect, State Key Lab Radiat Med & Protect,Med Coll, Suzhou, Peoples R China

来源：

FRONTIERS IN PUBLIC HEALTH | 2022年 / 10卷

关键词：

radiation-induced intestinal injury; biomarker; gut bacteria; gut bacteria related metabolite; radiotherapy; MICROBIOTA; DAMAGE;

D O I：

10.3389/fpubh.2022.862598

中图分类号：

R1 [预防医学、卫生学];

学科分类号：

1004 ; 120402 ;

摘要：

It is difficult to study the intestinal damage induced by space radiation to astronauts directly, and few prediction models exist. However, we can simulate it in patients with pelvic tumor radiotherapy (RT). Radiation-induced intestinal injury (RIII) is common in cancer patients who receieved pelvic and abdominal RT. We dynamically analyzed gut microbiota and metabolites alterations in 17 cervical and endometrial cancer patients after pelvic RT. In patients who later developed grade 2 RIII, dysbiosis of gut microbiota and metabolites were observed. Univariate analysis showed that Erysipelatoclostridium and ptilosteroid A were related to the occurrence of grade 2 RIII. Notably, a strong positive correlation between gut bacteria Erysipelatoclostridium relative abundance and gut metabolite ptilosteroid A expression was found. Furthermore, combinations of Erysipelatoclostridium and ptilosteroid A could provide good diagnostic markers for grade 2 RIII. In conclusion, gut bacteria Erysipelatoclostridium and its related metabolite ptilosteroid A may collaboratively predict RIII, and could be diagnostic biomarkers for RIII and space radiation injury.

引用

页数：10

共 24 条

[1] The intestinal microbiome in early life: health and disease [J].

Arrieta, Marie-Claire ;

Stiemsma, Leah T. ;

Amenyogbe, Nelly ;

Brown, Eric M. ;

Finlay, Brett .

FRONTIERS IN IMMUNOLOGY, 2014, 5

[2] Radiation oncology in the era of precision medicine [J].

Baumann, Michael ;

Krause, Mechthild ;

Overgaard, Jens ;

Debus, Juergen ;

Bentzen, Soren M. ;

Daartz, Juliane ;

Richter, Christian ;

Zips, Daniel ;

Bortfeld, Thomas .

NATURE REVIEWS CANCER, 2016, 16 (04) :234-249

[3] Crosstalk between Gut Microbiota and Dietary Lipids Aggravates WAT Inflammation through TLR Signaling [J].

Caesar, Robert ;

Tremaroli, Valentina ;

Kovatcheva-Datchary, Petia ;

Cani, Patrice D. ;

Backhed, Fredrik .

CELL METABOLISM, 2015, 22 (04) :658-668

[4] Dead or Alive: Molecular Assessment of Microbial Viability [J].

Cangelosi, Gerard A. ;

Meschke, John S. .

APPLIED AND ENVIRONMENTAL MICROBIOLOGY, 2014, 80 (19) :5884-5891

[5] Metabolic endotoxemia initiates obesity and insulin resistance [J].

Cani, Patrice D. ;

Amar, Jacques ;

Iglesias, Miguel Angel ;

Poggi, Marjorie ;

Knauf, Claude ;

Bastelica, Delphine ;

Neyrinck, Audrey M. ;

Fava, Francesca ;

Tuohy, Kieran M. ;

Chabo, Chantal ;

Waget, Aurelie ;

Delmee, Evelyne ;

Cousin, Beatrice ;

Sulpice, Thierry ;

Chamontin, Bernard ;

Ferrieres, Jean ;

Tanti, Jean-Francois ;

Gibson, Glenn R. ;

Casteilla, Louis ;

Delzenne, Nathalie M. ;

Alessi, Marie Christine ;

Burcelin, Remy .

DIABETES, 2007, 56 (07) :1761-1772

[6]

Cao X P, 2020, Zhonghua Wei Chang Wai Ke Za Zhi, V23, P734, DOI 10.3760/cma.j.cn.441530-20200505-00254

[7] Application of 1H NMR spectroscopy-based metabonomics to feces of cervical cancer patients with radiation-induced acute intestinal symptoms [J].

Chai, Yanlan ;

Wang, Juan ;

Wang, Tao ;

Yang, Yunyi ;

Su, Jin ;

Shi, Fan ;

Wang, Jiquan ;

Zhou, Xi ;

He, Bin ;

Ma, Hailin ;

Liu, Zi .

RADIOTHERAPY AND ONCOLOGY, 2015, 117 (02) :294-301

[8] Microbial regulation of intestinal radiosensitivity [J].

Crawford, PA ;

Gordon, JI .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2005, 102 (37) :13254-13259

[9] Diet rapidly and reproducibly alters the human gut microbiome [J].

David, Lawrence A. ;

Maurice, Corinne F. ;

Carmody, Rachel N. ;

Gootenberg, David B. ;

Button, Julie E. ;

Wolfe, Benjamin E. ;

Ling, Alisha V. ;

Devlin, A. Sloan ;

Varma, Yug ;

Fischbach, Michael A. ;

Biddinger, Sudha B. ;

Dutton, Rachel J. ;

Turnbaugh, Peter J. .

NATURE, 2014, 505 (7484) :559-+

[10] Microbial community gene expression in ocean surface waters [J].

Frias-Lopez, Jorge. ;

Shi, Yanmei ;

Tyson, Gene W. ;

Coleman, Maureen L. ;

Schuster, Stephan C. ;

Chisholm, Sallie W. ;

DeLong, Edward F. .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2008, 105 (10) :3805-3810

← 1 2 3 →