Epidemiology, clinicalfeatures anddiagnosticwork-up of cysticneoplasms of the pancreas: Interim analysis of the prospective PANCY survey

被引：25

作者：

Pezzilli, Raffaele ^{[1
]}

Buscarini, Elisabetta ^{[2
]}

Pollini, Tommaso ^{[3
]}

Bonamini, Deborah ^{[3
]}

Marchegiani, Giovanni ^{[3
]}

Crippa, Stefano ^{[4
]}

Belfiori, Giulio ^{[4
]}

Sperti, Cosimo ^{[5
]}

Moletta, Lucia ^{[5
]}

Pozza, Gioia ^{[5
]}

De Nucci, Germana ^{[6
]}

Manes, Giampiero ^{[6
]}

Mandelli, Enzo D. ^{[6
]}

Casadei, Riccardo ^{[7
]}

Ricci, Claudio ^{[7
]}

Alicante, Saverio ^{[2
]}

Vattiato, Claudia ^{[2
]}

Carrara, Silvia ^{[8
]}

Di Leo, Milena ^{[8
]}

Fabbri, Carlo ^{[9
]}

Giovanelli, Silvia ^{[10
]}

Barresi, Luca ^{[11
]}

Tacelli, Matteo ^{[11
]}

Mirante, Vincenzo G. ^{[12
]}

Conigliaro, Rita ^{[12
]}

Antonini, Filippo ^{[13
]}

Macarri, Giampiero ^{[13
]}

Frulloni, Luca ^{[14
]}

De Marchi, Giulia ^{[14
]}

Sassatelli, Romano ^{[15
]}

Cecinato, Paolo ^{[15
]}

Blanco, Giovanna Del Vecchio P. ^{[16
]}

Galli, Andrea ^{[17
]}

Pezzullo, Angelo ^{[18
]}

Fantin, Alberto ^{[19
]}

Graffeo, Massimo ^{[20
]}

Frego, Mauro ^{[21
]}

Stillittano, Domenico ^{[22
]}

Monica, Fabio ^{[23
]}

Germana, Bastianello ^{[24
]}

Capurso, Gabriele ^{[25
,29
]}

Quartini, Mariano ^{[26
]}

Veneroni, Luigi ^{[27
]}

Cannizzaro, Renato ^{[28
]}

Falconi, Massimo ^{[4
]}

机构：

[1] San Carlo Hosp, Dept Gastroenterol, Via P Petrone, I-85100 Potenza, Italy

[2] Maggiore Hosp, Gastroenterol & Endoscopy Unit, Crema, Italy

[3] Verona Univ, Pancreas Inst, Verona, Italy

[4] Univ Vita Salute San Raffaele, Pancreas Translat & Clin Res Ctr, IRCCS San Raffaele Sci Inst, Pancreat Surg Unit, Milan, Italy

[5] Univ Padua, Dept Surg Oncol & Gastroenterol Sci, Padua, Italy

[6] Rhodense Hosp, Gastroenterol & Endoscopy Unit, Milan, Italy

[7] Univ Bologna, Surg Dept, Polyclin St Orsola, Bologna, Italy

[8] IRCCS, Div Gastroenterol, Digest Endoscopy Unit, Humanitas Clin & Res Ctr, Milan, Italy

[9] Unit Gastroenterol & Digest Endoscopy, Forli Cesena, Italy

[10] Maggiore Hosp, Gastroenterol & Intervent Endoscopy Unit, Bologna, Italy

[11] IRCCS ISMETT Mediterranean Inst Transplantat & Hi, Dept Diag & Therapeut Serv, Endoscopy Serv, Palermo, Italy

[12] Univ Hosp, Baggiovara Hosp, Gastroenterol & Endoscopy Unit, Modena, Italy

[13] Polytech Univ Marche, Augusto Murri Hosp, Gastroenterol & Digest Endoscopy Unit, Fermo, Italy

[14] Univ Verona Hosp Trust, Pancreas Inst, Dept Med, Gastroenterol, Verona, Italy

[15] IRCCS Hosp, Reggio Emilia, Italy

[16] Tor Vergata Univ, Dept Med, Unit Gastroenterol, Rome, Italy

[17] Dept Expt & Clin Biomed Sci, Gastroenterol Res Unit, Florence, Italy

[18] Univ Naples Federico II, Dept Anesthesiol Surg & Emergency Sci, Naples, Italy

[19] Gastroenterol Unit, Padua, Italy

[20] Poliambulanza Hosp, Dept Internal Med, Gastroenterol & Endoscopy, Brescia, Italy

[21] Osped Riuniti, Surg Dept, Padua, Italy

[22] Desio Hosp, Digest Endoscopy Unit, Milan, Italy

[23] Cattinara Hosp, Gastroenterol & Digest Endoscopy, Trieste, Italy

[24] San Martino Hosp, Gastroenterol Unit, Belluno, Italy

[25] S Andrea Hosp, Digest & Liver Dis Unit, Rome, Italy

[26] St Maria Hosp, Gastroenterol Unit, Terni, Italy

[27] Infermi Hosp, Surg Dept, Rimini, Italy

[28] Oncol Ctr, Aviano, Italy

[29] Univ Vita Salute San Raffaele, Pancreas Ctr, IRCCS San Raffaele Sci Inst, Pancreaticobiliary & EUS Unit, Milan, Italy

来源：

DIGESTIVE AND LIVER DISEASE | 2020年 / 52卷 / 05期

关键词：

Biomarkers; Cystic neoplasm; Cytology; Endosonography; Epidemiology Magnetic resonance imaging; Multidetector computed tomography; Pancreatic cyst; PAPILLARY MUCINOUS NEOPLASM; CYSTIC NEOPLASMS; DIAGNOSIS; GUIDELINES; MANAGEMENT; PREVALENCE; AMYLASE; CEA; EUS;

D O I：

10.1016/j.dld.2020.02.003

中图分类号：

R57 [消化系及腹部疾病];

学科分类号：

摘要：

Introduction: A prospective survey to evaluate the diagnostic workup of cystic pancreatic neoplasms (CPNs) according to the Italian guidelines. Methods: An online data sheet was built. Results: Fifteen of the 1385 patients (1.1%) had non cystic neoplastic lesions. Forty percent (518/1295) had at least one 1st degree relative affected by a solid tumor of the digestive and extra-digestive organs. Symptoms/signs associated with the cystic lesion were present in 24.5% of the patients. The cysts were localized in the head of the pancreas in 38.5% of patients. Of the 2370 examinations (1.7 examinations per patient) which were carried out for the diagnosis, magnetic resonance imaging was performed as a single test in 48.4% of patients and in combination with endoscopic ultrasound in 27% of the cases. Of the 1370 patients having CPNs, 89.9% had an intraductal papillary mucinous neoplasm (IPMN) (70.1% a branch duct IPMN, 6.2% a mixed type IPMN and 4.6% a main duct IPMN), 12.7% had a serous cystadenoma, 2.8% a mucinous cystadenoma, 1.5% a non-functioning cystic neuroendocrine neoplasm, 0.7% a solid-pseudopapillary cystic neoplasm, 0.3% a cystic adenocarcinoma, and 1.2% an undetermined cystic neoplasm. Seventy-eight (5.7%) patients were operated upon after the initial work-up. Conclusions: This prospective study offers a reliable real-life picture of the diagnostic work-up CPN. (C) 2020 Editrice Gastroenterologica Italiana S.r.l. Published by Elsevier Ltd. All rights reserved.

引用

页码：547 / 554

页数：8

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