The Role of ATRA, Natural Ligand of Retinoic Acid Receptors, on EMT-Related Proteins in Breast Cancer: Minireview

被引：10

作者：

Bobal, Pavel ^{[1
]}

Lastovickova, Marketa ^{[2
]}

Bobalova, Janette ^{[2
]}

机构：

[1] Masaryk Univ, Dept Chem Drugs, Fac Pharm, Brno 61200, Czech Republic

[2] CAS, Vvi, Inst Analyt Chem, Brno 60200, Czech Republic

来源：

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES | 2021年 / 22卷 / 24期

关键词：

breast cancer; EMT; protein; ATRA; EPITHELIAL-MESENCHYMAL TRANSITION; PROTEOMIC ANALYSIS; TRIORGANOTIN COMPOUNDS; STEM-CELLS; EXPRESSION; CD44; METASTASIS; MECHANISMS; REXINOIDS; CHEMOPREVENTION;

D O I：

10.3390/ijms222413345

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The knowledge of the structure, function, and abundance of specific proteins related to the EMT process is essential for developing effective diagnostic approaches to cancer with the perspective of diagnosis and therapy of malignancies. The success of all-trans retinoic acid (ATRA) differentiation therapy in acute promyelocytic leukemia has stimulated studies in the treatment of other tumors with ATRA. This review will discuss the impact of ATRA use, emphasizing epithelial-mesenchymal transition (EMT) proteins in breast cancer, of which metastasis and recurrence are major causes of death.

引用

页数：18

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