Genomic assessment of quarantine measures to prevent SARS-CoV-2 importation and transmission

被引：10

作者：

Aggarwal, Dinesh ^{[1
,2
,3
,4
]}

Page, Andrew J. ^{[5
]}

Schaefer, Ulf ^{[2
]}

Savva, George M. ^{[5
]}

Myers, Richard ^{[2
]}

Volz, Erik ^{[6
]}

Ellaby, Nicholas ^{[2
]}

Platt, Steven ^{[2
]}

Groves, Natalie ^{[2
]}

Gallagher, Eileen ^{[2
]}

Tumelty, Niamh M. ^{[7
]}

Thanh Le Viet ^{[5
]}

Hughes, Gareth J. ^{[8
]}

Chen, Cong ^{[2
]}

Turner, Charlie ^{[2
]}

Logan, Sophie ^{[9
]}

Harrison, Abbie ^{[2
]}

Peacock, Sharon J. ^{[1
,2
,3
,4
]}

Chand, Meera ^{[2
]}

Harrison, Ewan M. ^{[1
,2
,4
,10
]}

机构：

[1] Univ Cambridge, Dept Med, Cambridge, England

[2] Publ Hlth England, 61 Colindale Ave, London NW9 5EQ, England

[3] Cambridge Univ Hosp NHS Fdn Trust, Cambridge, England

[4] Wellcome Sanger Inst, Cambridge, England

[5] Norwich Res Pk, Quadram Inst Biosci, Norwich NR4 7UQ, Norfolk, England

[6] Imperial Coll London, Dept Infect Dis Epidemiol, London, England

[7] Univ Cambridge, Cambridge Univ Lib, Cambridge, England

[8] Publ Hlth England Natl Infect Serv, Field Serv, Leeds, W Yorkshire, England

[9] Publ Hlth England, Field Serv, Natl Infect Serv, Nottingham, England

[10] Univ Cambridge, Dept Publ Hlth & Primary Care, Cambridge, England

来源：

NATURE COMMUNICATIONS | 2022年 / 13卷 / 01期

基金：

英国惠康基金; 英国医学研究理事会; 英国生物技术与生命科学研究理事会; 英国科研创新办公室;

关键词：

D O I：

10.1038/s41467-022-28371-z

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

Post-international travel quarantine has been widely implemented to mitigate SARS-CoV-2 transmission, but the impacts of such policies are unclear. Here, the authors used linked genomic and contact tracing data to assess the impacts of a 14-day quarantine on return to England in summer 2020. Mitigation of SARS-CoV-2 transmission from international travel is a priority. We evaluated the effectiveness of travellers being required to quarantine for 14-days on return to England in Summer 2020. We identified 4,207 travel-related SARS-CoV-2 cases and their contacts, and identified 827 associated SARS-CoV-2 genomes. Overall, quarantine was associated with a lower rate of contacts, and the impact of quarantine was greatest in the 16-20 age-group. 186 SARS-CoV-2 genomes were sufficiently unique to identify travel-related clusters. Fewer genomically-linked cases were observed for index cases who returned from countries with quarantine requirement compared to countries with no quarantine requirement. This difference was explained by fewer importation events per identified genome for these cases, as opposed to fewer onward contacts per case. Overall, our study demonstrates that a 14-day quarantine period reduces, but does not completely eliminate, the onward transmission of imported cases, mainly by dissuading travel to countries with a quarantine requirement.

引用

页数：13

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