Physicochemical and Biological Study of 99mTc and 68Ga Radiolabelled Ciprofloxacin and Evaluation of [99mTc]Tc-CIP as Potential Diagnostic Radiopharmaceutical for Diabetic Foot Syndrome Imaging

被引：9

作者：

Kozminski, Przemyslaw ^{[1
]}

Gaweda, Weronika ^{[1
]}

Rzewuska, Magdalena ^{[2
]}

Kopatys, Agata ^{[3
]}

Kujda, Szymon ^{[3
]}

Dudek, Marta K. ^{[4
]}

Halik, Pawel Krzysztof ^{[1
]}

Krolicki, Leszek ^{[3
]}

Gniazdowska, Ewa ^{[1
]}

机构：

[1] Inst Nucl Chem & Technol, Ctr Radiochem & Nucl Chem, Dorodna 16, PL-03195 Warsaw, Poland

[2] Warsaw Univ Life Sci SGGW, Div Microbiol, Dept Preclin Sci, Inst Vet Med, Ciszewskiego 8, PL-02786 Warsaw, Poland

[3] Med Univ Warsaw, Dept Nucl Med, Banacha 1a, PL-02097 Warsaw, Poland

[4] Polish Acad Sci, Ctr Mol & Macromol Studies, Sienkiewicza 112, PL-90363 Lodz, Poland

来源：

TOMOGRAPHY | 2021年 / 7卷 / 04期

关键词：

ciprofloxacin; technetium-99m; gallium-68; radiopharmaceutical; bacterial infection; diabetic foot; BACTERIAL-INFECTION; RADIOTRACERS;

D O I：

10.3390/tomography7040070

中图分类号：

R8 [特种医学]; R445 [影像诊断学];

学科分类号：

1002 ; 100207 ; 1009 ;

摘要：

This paper presents the application of ciprofloxacin as a biologically active molecule (vector) for delivering diagnostic radiopharmaceuticals to the sites of bacterial infection. Ciprofloxacin-based radioconjugates containing technetium-99m or gallium-68 radionuclides were synthesised, and their physicochemical (stability, lipophilicity) and biological (binding study to Staphylococcus aureus and Pseudomonas aeruginosa) properties were investigated. Both the tested radiopreparations met the requirements for radiopharmaceuticals, and technetium-99m-labelled ciprofloxacin turned out to be a good radiotracer for the tomography of diabetic foot syndrome using SPECT.

引用

页码：829 / 842

页数：14

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