Effect of varicoceles on spermatogenesis

被引：30

作者：

Kang, Caroline ^{[1
]}

Punjani, Nahid ^{[1
]}

Lee, Richard K. ^{[1
]}

Li, Philip S. ^{[1
]}

Goldstein, Marc ^{[1
]}

机构：

[1] New York Presbyterian Hosp, Dept Urol, Weill Cornell Med, 525 East 68th St,Starr 900, New York, NY 10065 USA

来源：

SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY | 2022年 / 121卷

关键词：

Varicocele; Spermatogenesis; Testicular dysfunction; Testosterone deficiency; Oxidative stress; Male infertility; BINDING PROTEIN CIRP; GERM-CELL APOPTOSIS; OXIDATIVE STRESS; MALE-INFERTILITY; LEYDIG-CELL; OLIGOSPERMIC MEN; TESTICULAR DYSFUNCTION; INCREASED EXPRESSION; DNA FRAGMENTATION; REFERENCE VALUES;

D O I：

10.1016/j.semcdb.2021.04.005

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

Varicoceles are dilated veins within the spermatic cord and a relatively common occurrence in men. Fortunately, the large majority of men are asymptomatic, however, a proportion of men with varicoceles can suffer from infertility and testosterone deficiency. Sperm and testosterone are produced within the testis, and any alteration to the testicular environment can negatively affect the cells responsible for these processes. The negative impact of varicoceles on testicular function occurs mainly due to increased oxidative stress within the testicular parenchyma which is thought to be caused by scrotal hyperthermia, testicular hypoxia, and blood-testis barrier disruption. Management of varicoceles involves ligation or percutaneous embolization of the dilated veins. Repair of varicoceles can improve semen parameters and fertility, along with serum testosterone concentration. In this review, we discuss the pathophysiology of varicoceles, their impact on testicular function, and management.

引用

页码：114 / 124

页数：11

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