Waveguide Mach-Zehnder biosensor with laser diode pumped integrated single-mode silicon nitride organic hybrid solid-state laser

被引:20
作者
Vogelbacher, Florian [1 ,3 ]
Kothe, Tim [1 ]
Muellner, Paul [1 ]
Melnik, Eva [1 ]
Sagmeister, Martin [2 ]
Kraft, Jochen [2 ]
Hainberger, Rainer [1 ]
机构
[1] AIT Austrian Inst Technol GmbH, Ctr Hlth & Bioresources, Giefinggasse, A-1210 Vienna, Austria
[2] Ams AG, Tobelbader Str 8141, A-8141 Premstatten, Austria
[3] Chinese Acad Sci, Inst Chem, Key Lab Green Printing, Beijing 100190, Peoples R China
关键词
Organic solid-state laser; Distributed feedback; Optical waveguide biosensor; Mach-Zehnder interferometer; Silicon nitride; Point-of-care diagnostics; REFRACTIVE-INDEX; INTERFEROMETERS;
D O I
10.1016/j.bios.2021.113816
中图分类号
Q6 [生物物理学];
学科分类号
071011 ;
摘要
Single-mode organic solid-state lasers with direct emission into an optical waveguide are attractive candidates for cost-efficient coherent light sources employed in photonic lab-on-a-chip biosensors. Here, we present a combination of a dye-doped organic solid-state distributed feedback laser with a highly sensitive optical waveguide Mach-Zehnder interferometer on a silicon nitride photonic platform. This organic-hybrid laser allows for optical pumping with a laser diode in an alignment tolerant manner, which facilitates applications in point-ofcare diagnostics. The sensitivity to bulk refractive index changes and the concentration dependent binding of streptavidin on a polyethyleneimine-biotin functionalized surface was studied to demonstrate the practicability of this cost-efficient coherent light source for optical waveguide biosensors.
引用
收藏
页数:7
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