Targeted therapy of SMMC-7721 liver cancer in vitro and in vivo with carbon nanotubes based drug delivery system

被引：169

作者：

Ji, Zongfei ^{[3
]}

Lin, Gaofeng ^{[1
]}

Lu, Qinghua ^{[1
,2
]}

Meng, Lingjie ^{[1
,2
]}

Shen, Xizhong ^{[3
]}

Dong, Ling ^{[3
]}

Fu, Chuanlong ^{[1
]}

Zhang, Xiaoke ^{[1
]}

机构：

[1] Shanghai Jiao Tong Univ, Sch Chem & Chem Engn, Dept Polymer Sci & Engn, Shanghai 200240, Peoples R China

[2] Shanghai Jiao Tong Univ, State Key Lab Met Matrix Composites, Shanghai 200240, Peoples R China

[3] Fudan Univ, Zhongshan Hosp, Dept Gastroenterol, Shanghai 200032, Peoples R China

来源：

JOURNAL OF COLLOID AND INTERFACE SCIENCE | 2012年 / 365卷 / 01期

基金：

美国国家科学基金会;

关键词：

Carbon nanotubes; Chitosan; Folic acid; Drug delivery system; Liver cancer; DOXORUBICIN; FOLATE; NANOPARTICLES; TRANSPORTERS; FUNCTIONALIZATION; CHEMOTHERAPY; COPOLYMER; RELEASE; BLOOD;

D O I：

10.1016/j.jcis.2011.09.013

中图分类号：

O64 [物理化学（理论化学）、化学物理学];

学科分类号：

070304 ; 081704 ;

摘要：

A new type of drug delivery system (DDS) involved chitosan (CHI) modified single walled carbon nanotubes (SWNTs) for controllable loading/release of anti-cancer doxorubicin (DOX) was constructed. CHI was non-covalently wrapped around SWNTs, imparting water-solubility and biocompatibility to the nanotubes. Folic acid (FA) was also bounded to the outer CHI layer to realize selective killing of tumor cells. The targeting DDS could effectively kill the HCC SMMC-7721 cell lines and depress the growth of liver cancer in nude mice, showing superior pharmaceutical efficiency to free DOX. The results of the blood routine and serum biochemical parameters, combined with the histological examinations of vital organs, demonstrating that the targeting DDS had negligible in vivo toxicity. Thus, this DDS is promising for high treatment efficacy and low side effects for future cancer therapy. (C) 2011 Elsevier Inc. All rights reserved.

引用

页码：143 / 149

页数：7

共 48 条

[1] Functional Folate Receptor Alpha Is Elevated in the Blood of Ovarian Cancer Patients [J].

Basal, Eati ;

Eghbali-Fatourechi, Guiti Z. ;

Kalli, Kimberly R. ;

Hartmann, Lynn C. ;

Goodman, Karin M. ;

Goode, Ellen L. ;

Kamen, Barton A. ;

Low, Philip S. ;

Knutson, Keith L. .

PLOS ONE, 2009, 4 (07)

[2] Reliability of the Roenigk classification of liver damage after methotrexate treatment for psoriasis [J].

Berends, Maartje A. M. ;

van Oijen, Martijn G. H. ;

Snoek, Josje ;

de Kerkhof, Peter C. M. van ;

Drenth, Joost P. H. ;

van Krieken, J. Han ;

de Jong, Elke M. G. J. .

ARCHIVES OF DERMATOLOGY, 2007, 143 (12) :1515-1519

[3] Targeted Killing of Cancer Cells in Vivo and in Vitro with EGF-Directed Carbon Nanotube-Based Drug Delivery [J].

Bhirde, Ashwin A. ;

Patel, Vyomesh ;

Gavard, Julie ;

Zhang, Guofeng ;

Sousa, Alioscka A. ;

Masedunskas, Andrius ;

Leapman, Richard D. ;

Weigert, Roberto ;

Gutkind, J. Silvio ;

Rusling, James F. .

ACS NANO, 2009, 3 (02) :307-316

[4] Applications of carbon nanotubes in drug delivery [J].

Bianco, A ;

Kostarelos, K ;

Prato, M .

CURRENT OPINION IN CHEMICAL BIOLOGY, 2005, 9 (06) :674-679

[5]

Chen J., 2009, PROG MOD BIOMED, V9, P3006

[6] Reversible Accumulation of PEGylated Single-Walled Carbon Nanotubes in the Mammalian Nucleus [J].

Cheng, Jinping ;

Fernando, K. A. Shiral ;

Veca, L. Monica ;

Sun, Ya-Ping ;

Lamond, Angus I. ;

Lam, Yun Wah ;

Cheng, Shuk Han .

ACS NANO, 2008, 2 (10) :2085-2094

[7] Targeted single-wall carbon nanotube-mediated Pt(IV) prodrug delivery using folate as a homing device [J].

Dhar, Shanta ;

Liu, Zhuang ;

Thomale, Juergen ;

Dai, Hongjie ;

Lippard, Stephen J. .

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 2008, 130 (34) :11467-11476

[8] Role of folate receptor genes in reproduction and related cancers [J].

Elnakat, H ;

Ratnam, M .

FRONTIERS IN BIOSCIENCE-LANDMARK, 2006, 11 :506-519

[9] Soluble single-walled carbon nanotubes as longboat delivery systems for Platinum(IV) anticancer drug design [J].

Feazell, Rodney P. ;

Nakayama-Ratchford, Nozomi ;

Dai, Hongjie ;

Lippard, Stephen J. .

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 2007, 129 (27) :8438-+

[10] Targeted delivery and triggered release of liposomal doxorubicin enhances cytotoxicity against human B lymphoma cells [J].

Ishida, T ;

Kirchmeier, MJ ;

Moase, EH ;

Zalipsky, S ;

Allen, TM .

BIOCHIMICA ET BIOPHYSICA ACTA-BIOMEMBRANES, 2001, 1515 (02) :144-158

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