Synthesis of 4,4-disubstituted L-glutamic acids by enzymatic transamination

被引：0

作者：

Hélaine, V ^{[1
]}

Rossi, J ^{[1
]}

Gefflaut, T ^{[1
]}

Alaux, S ^{[1
]}

Bolte, J ^{[1
]}

机构：

[1] Univ Clermont Ferrand, Lab SEESIB, UMR CNRS 6504, Dept Chim, F-63177 Clermont Ferrand, France

来源：

ADVANCED SYNTHESIS & CATALYSIS | 2001年 / 343卷 / 6-7期

关键词：

amino acids; biotransformations; enzyme catalysis; glutamate analogues; transamination; transferases;

D O I：

10.1002/1615-4169(200108)343:6/7<692::AID-ADSC692>3.0.CO;2-6

中图分类号：

O69 [应用化学];

学科分类号：

081704 ;

摘要：

The syntheses of optically pure 4,4-dimethyl-L-glutamic acid as well as (2S,4R)- and (2S,4S)-4-hydroxy-4-methylglutamic acids have been achieved by transamination of the corresponding 2-oxo-4,4-dimethyl- and rac-2-oxo-4-hydroxy-4-methylglutaric acids using glutamic oxalacetic transaminase (GOT).

引用

页码：692 / 697

页数：6

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