Palladium-catalyzed cross-coupling of benzyltitanium(IV) reagents with aryl fluorides

被引：2
|
作者：
Li, Yan [1 ]
机构：
[1] Hebei Chem & Pharmaceut Coll, Dept Chem & Environm Engn, Shijiazhuang, Hebei, Peoples R China
来源：
MONATSHEFTE FUR CHEMIE | 2022年 / 153卷 / 02期
关键词：
Diarylmethane; C-C bond; Aryl fluorides; TM-catalyzed; Aryl titanium reagents; FUNCTIONALIZATION; HALIDES;
D O I：
10.1007/s00706-021-02881-w
中图分类号：
O6 [化学];
学科分类号：
0703 ;
摘要：
The first palladium-catalyzed cross-coupling between benzyltitanium(IV) reagents with aryl fluorides is reported. A variety of diarylmethanes can be prepared in good to excellent yields by the catalyst system of PdCl2 (dppf)(2) associated with 1-[2-(di-tert-butylphosphanyl)phenyl]-4-methoxypiperidine. This reaction offered a highly efficient approach to diarylmethanes that are commonly found in life-changing drug molecules. [GRPHICS].
引用
收藏
页码：193 / 199
页数：7
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