Introduction: While amnestic mild cognitive impairment (aMCI) and non-amnestic mild cognitive impairment (naMCI) are theoretically different entities, only a few investigations studied the structural brain differences between these subtypes of mild cognitive impairment. The aim of the study was to find the structural differences between aMCI and naMCI, and to replicate previous findings on the differentiation between aMCI and healthy controls. Methods: Altogether 62 aMCI, naMCI, and healthy control subjects were included into the study based on the Petersen criteria. All patients underwent a routine brain MR examination, and a detailed neuropsychological examination. Results: The sizes of the hippocampus, the entorhinal cortex and the amygdala were decreased in aMCI relative to naMCI and to controls. Furthermore the cortical thickness of the entorhinal cortex, the fusiform gyrus, the precuneus and the isthmus of the cingulate gyrus were significantly decreased in aMCI relative to naMCI and healthy controls. The largest differences relative to controls were detected for the volume of the hippocampus (18% decrease vs. controls) and the cortical thickness (20% decrease vs. controls) of the entorhinal cortex: 1.6 and 1.4 in terms of Cohen's d. Only the volume of the precuneus were decreased in the naMCI group (5% decrease) compared to the control subjects: 0.9 in terms of Cohen's d. Significant between group differences were also found in the neuropsychological test results: a decreased anterograde, retrograde memory, and category fluency performance was detected in the aMCI group relative to controls and naMCI subjects. Subjects with naMCI showed decreased letter fluency relative to controls, while both MCI groups showed decreased executive functioning relative to controls as measured by the Trail Making test part B. Memory performance in the aMCI group and in the entire sample correlated with the thickness of the entorhinal cortex and with the volume of the amygdala. Conclusion: The amnestic mild cognitive impairment/non-amnestic mild cognitive impairment separation is not only theoretical but backed by structural imaging methods and neuropsychological tests. A better knowledge of the MCI subtypes can help to predict the direction of progression and create targeted prevention.
机构:
Univ Virginia, Dept Neurol, Charlottesville, VA USA
Univ Virginia, Off Dean, Charlottesville, VA USAJohns Hopkins Univ, Sch Med, Dept Neurol, Baltimore, MD 21205 USA
DeKosky, Steven T.
;
Dickson, Dennis
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h-index: 0
机构:
Mayo Clin, Dept Pathol, Jacksonville, FL 32224 USAJohns Hopkins Univ, Sch Med, Dept Neurol, Baltimore, MD 21205 USA
机构:
Univ Calif San Diego, Dept Neurosci, San Diego, CA 92103 USAJohns Hopkins Univ, Sch Med, Dept Neurol, Baltimore, MD 21205 USA
Gamst, Anthony
;
Holtzman, David M.
论文数: 0引用数: 0
h-index: 0
机构:
Washington Univ, Dept Neurol, St Louis, MO USA
Washington Univ, Knight Alzheimers Dis Res Ctr, St Louis, MO USAJohns Hopkins Univ, Sch Med, Dept Neurol, Baltimore, MD 21205 USA
Holtzman, David M.
;
Jagust, William J.
论文数: 0引用数: 0
h-index: 0
机构:
Univ Calif Berkeley, Helen Wills Neurosci Inst, Berkeley, CA 94720 USAJohns Hopkins Univ, Sch Med, Dept Neurol, Baltimore, MD 21205 USA
Jagust, William J.
;
Petersen, Ronald C.
论文数: 0引用数: 0
h-index: 0
机构:
Mayo Clin, Dept Neurol, Rochester, MN USAJohns Hopkins Univ, Sch Med, Dept Neurol, Baltimore, MD 21205 USA
Petersen, Ronald C.
;
Snyder, Peter J.
论文数: 0引用数: 0
h-index: 0
机构:
Brown Univ, Rhode Isl Hosp, Alpert Med Sch, Providence, RI 02903 USA
Brown Univ, Dept Neurol, Alpert Med Sch, Providence, RI 02912 USAJohns Hopkins Univ, Sch Med, Dept Neurol, Baltimore, MD 21205 USA
Snyder, Peter J.
;
Carrillo, Maria C.
论文数: 0引用数: 0
h-index: 0
机构:
Alzheimers Assoc, Chicago, IL USAJohns Hopkins Univ, Sch Med, Dept Neurol, Baltimore, MD 21205 USA
Carrillo, Maria C.
;
Thies, Bill
论文数: 0引用数: 0
h-index: 0
机构:
Alzheimers Assoc, Chicago, IL USAJohns Hopkins Univ, Sch Med, Dept Neurol, Baltimore, MD 21205 USA
机构:
Univ Calif San Francisco, Dept Radiol, San Francisco, CA 94143 USA
Vet Affairs Med Ctr, Ctr Imaging Neurodegenerat Dis, San Francisco, CA 94121 USAUniv Calif San Francisco, Dept Radiol, San Francisco, CA 94143 USA
Chiang, Gloria C.
;
Insel, Philip S.
论文数: 0引用数: 0
h-index: 0
机构:
Vet Affairs Med Ctr, Ctr Imaging Neurodegenerat Dis, San Francisco, CA 94121 USAUniv Calif San Francisco, Dept Radiol, San Francisco, CA 94143 USA
Insel, Philip S.
;
Tosun, Duygu
论文数: 0引用数: 0
h-index: 0
机构:
Univ Calif San Francisco, Dept Radiol, San Francisco, CA 94143 USA
Vet Affairs Med Ctr, Ctr Imaging Neurodegenerat Dis, San Francisco, CA 94121 USAUniv Calif San Francisco, Dept Radiol, San Francisco, CA 94143 USA
Tosun, Duygu
;
Schuff, Norbert
论文数: 0引用数: 0
h-index: 0
机构:
Univ Calif San Francisco, Dept Radiol, San Francisco, CA 94143 USA
Vet Affairs Med Ctr, Ctr Imaging Neurodegenerat Dis, San Francisco, CA 94121 USAUniv Calif San Francisco, Dept Radiol, San Francisco, CA 94143 USA
Schuff, Norbert
;
Truran-Sacrey, Diana
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机构:
Vet Affairs Med Ctr, Ctr Imaging Neurodegenerat Dis, San Francisco, CA 94121 USAUniv Calif San Francisco, Dept Radiol, San Francisco, CA 94143 USA
Truran-Sacrey, Diana
;
Raptentsetsang, Sky
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机构:
Vet Affairs Med Ctr, Ctr Imaging Neurodegenerat Dis, San Francisco, CA 94121 USAUniv Calif San Francisco, Dept Radiol, San Francisco, CA 94143 USA
Raptentsetsang, Sky
;
Jack, Clifford R., Jr.
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机构:
Mayo Clin, Dept Radiol, Rochester, MN USAUniv Calif San Francisco, Dept Radiol, San Francisco, CA 94143 USA
Jack, Clifford R., Jr.
;
Weiner, Michael W.
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h-index: 0
机构:
Univ Calif San Francisco, Dept Radiol, San Francisco, CA 94143 USA
Vet Affairs Med Ctr, Ctr Imaging Neurodegenerat Dis, San Francisco, CA 94121 USAUniv Calif San Francisco, Dept Radiol, San Francisco, CA 94143 USA
机构:
Massachusetts Gen Hosp, Dept Radiol, Athinoula A Martinos Ctr Biomed Imaging, Charlestown, MA 02129 USA
Boston Univ, Sch Med, Dept Anat & Neurobiol, Boston, MA 02118 USAMassachusetts Gen Hosp, Dept Radiol, Athinoula A Martinos Ctr Biomed Imaging, Charlestown, MA 02129 USA
Desikan, Rahul S.
;
Cabral, Howard J.
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h-index: 0
机构:
Boston Univ, Sch Publ Hlth, Dept Biostat, Boston, MA USAMassachusetts Gen Hosp, Dept Radiol, Athinoula A Martinos Ctr Biomed Imaging, Charlestown, MA 02129 USA
Cabral, Howard J.
;
Hess, Christopher P.
论文数: 0引用数: 0
h-index: 0
机构:
Univ Calif San Francisco, Dept Radiol, San Francisco, CA 94143 USAMassachusetts Gen Hosp, Dept Radiol, Athinoula A Martinos Ctr Biomed Imaging, Charlestown, MA 02129 USA
Hess, Christopher P.
;
Dillon, William P.
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h-index: 0
机构:
Univ Calif San Francisco, Dept Radiol, San Francisco, CA 94143 USAMassachusetts Gen Hosp, Dept Radiol, Athinoula A Martinos Ctr Biomed Imaging, Charlestown, MA 02129 USA
Dillon, William P.
;
Glastonbury, Christine M.
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机构:
Univ Calif San Francisco, Dept Radiol, San Francisco, CA 94143 USAMassachusetts Gen Hosp, Dept Radiol, Athinoula A Martinos Ctr Biomed Imaging, Charlestown, MA 02129 USA
Glastonbury, Christine M.
;
Weiner, Michael W.
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h-index: 0
机构:
Univ Calif San Francisco, Dept Radiol, San Francisco, CA 94143 USA
Vet Affairs Med Ctr, San Francisco, CA 94121 USAMassachusetts Gen Hosp, Dept Radiol, Athinoula A Martinos Ctr Biomed Imaging, Charlestown, MA 02129 USA
Weiner, Michael W.
;
Schmansky, Nicholas J.
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h-index: 0
机构:
Massachusetts Gen Hosp, Dept Radiol, Athinoula A Martinos Ctr Biomed Imaging, Charlestown, MA 02129 USAMassachusetts Gen Hosp, Dept Radiol, Athinoula A Martinos Ctr Biomed Imaging, Charlestown, MA 02129 USA
Schmansky, Nicholas J.
;
Greve, Douglas N.
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机构:
Massachusetts Gen Hosp, Dept Radiol, Athinoula A Martinos Ctr Biomed Imaging, Charlestown, MA 02129 USAMassachusetts Gen Hosp, Dept Radiol, Athinoula A Martinos Ctr Biomed Imaging, Charlestown, MA 02129 USA
Greve, Douglas N.
;
Salat, David H.
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Massachusetts Gen Hosp, Dept Radiol, Athinoula A Martinos Ctr Biomed Imaging, Charlestown, MA 02129 USAMassachusetts Gen Hosp, Dept Radiol, Athinoula A Martinos Ctr Biomed Imaging, Charlestown, MA 02129 USA
Salat, David H.
;
Buckner, Randy L.
论文数: 0引用数: 0
h-index: 0
机构:
Massachusetts Gen Hosp, Dept Radiol, Athinoula A Martinos Ctr Biomed Imaging, Charlestown, MA 02129 USA
Harvard Univ, Dept Psychol, Cambridge, MA 02138 USA
Howard Hughes Med Inst, Chevy Chase, MD USA
Massachusetts Gen Hosp, Dept Psychiat, Boston, MA 02114 USAMassachusetts Gen Hosp, Dept Radiol, Athinoula A Martinos Ctr Biomed Imaging, Charlestown, MA 02129 USA
Buckner, Randy L.
;
Fischl, Bruce
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机构:
Massachusetts Gen Hosp, Dept Radiol, Athinoula A Martinos Ctr Biomed Imaging, Charlestown, MA 02129 USA
MIT, CSAIL, Cambridge, MA 02139 USA
MIT, Harvard Mit Div Hlth Sci & Technol, Cambridge, MA 02139 USAMassachusetts Gen Hosp, Dept Radiol, Athinoula A Martinos Ctr Biomed Imaging, Charlestown, MA 02129 USA
机构:
Univ Virginia, Dept Neurol, Charlottesville, VA USA
Univ Virginia, Off Dean, Charlottesville, VA USAJohns Hopkins Univ, Sch Med, Dept Neurol, Baltimore, MD 21205 USA
DeKosky, Steven T.
;
Dickson, Dennis
论文数: 0引用数: 0
h-index: 0
机构:
Mayo Clin, Dept Pathol, Jacksonville, FL 32224 USAJohns Hopkins Univ, Sch Med, Dept Neurol, Baltimore, MD 21205 USA
机构:
Univ Calif San Diego, Dept Neurosci, San Diego, CA 92103 USAJohns Hopkins Univ, Sch Med, Dept Neurol, Baltimore, MD 21205 USA
Gamst, Anthony
;
Holtzman, David M.
论文数: 0引用数: 0
h-index: 0
机构:
Washington Univ, Dept Neurol, St Louis, MO USA
Washington Univ, Knight Alzheimers Dis Res Ctr, St Louis, MO USAJohns Hopkins Univ, Sch Med, Dept Neurol, Baltimore, MD 21205 USA
Holtzman, David M.
;
Jagust, William J.
论文数: 0引用数: 0
h-index: 0
机构:
Univ Calif Berkeley, Helen Wills Neurosci Inst, Berkeley, CA 94720 USAJohns Hopkins Univ, Sch Med, Dept Neurol, Baltimore, MD 21205 USA
Jagust, William J.
;
Petersen, Ronald C.
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h-index: 0
机构:
Mayo Clin, Dept Neurol, Rochester, MN USAJohns Hopkins Univ, Sch Med, Dept Neurol, Baltimore, MD 21205 USA
Petersen, Ronald C.
;
Snyder, Peter J.
论文数: 0引用数: 0
h-index: 0
机构:
Brown Univ, Rhode Isl Hosp, Alpert Med Sch, Providence, RI 02903 USA
Brown Univ, Dept Neurol, Alpert Med Sch, Providence, RI 02912 USAJohns Hopkins Univ, Sch Med, Dept Neurol, Baltimore, MD 21205 USA
Snyder, Peter J.
;
Carrillo, Maria C.
论文数: 0引用数: 0
h-index: 0
机构:
Alzheimers Assoc, Chicago, IL USAJohns Hopkins Univ, Sch Med, Dept Neurol, Baltimore, MD 21205 USA
Carrillo, Maria C.
;
Thies, Bill
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h-index: 0
机构:
Alzheimers Assoc, Chicago, IL USAJohns Hopkins Univ, Sch Med, Dept Neurol, Baltimore, MD 21205 USA
机构:
Univ Calif San Francisco, Dept Radiol, San Francisco, CA 94143 USA
Vet Affairs Med Ctr, Ctr Imaging Neurodegenerat Dis, San Francisco, CA 94121 USAUniv Calif San Francisco, Dept Radiol, San Francisco, CA 94143 USA
Chiang, Gloria C.
;
Insel, Philip S.
论文数: 0引用数: 0
h-index: 0
机构:
Vet Affairs Med Ctr, Ctr Imaging Neurodegenerat Dis, San Francisco, CA 94121 USAUniv Calif San Francisco, Dept Radiol, San Francisco, CA 94143 USA
Insel, Philip S.
;
Tosun, Duygu
论文数: 0引用数: 0
h-index: 0
机构:
Univ Calif San Francisco, Dept Radiol, San Francisco, CA 94143 USA
Vet Affairs Med Ctr, Ctr Imaging Neurodegenerat Dis, San Francisco, CA 94121 USAUniv Calif San Francisco, Dept Radiol, San Francisco, CA 94143 USA
Tosun, Duygu
;
Schuff, Norbert
论文数: 0引用数: 0
h-index: 0
机构:
Univ Calif San Francisco, Dept Radiol, San Francisco, CA 94143 USA
Vet Affairs Med Ctr, Ctr Imaging Neurodegenerat Dis, San Francisco, CA 94121 USAUniv Calif San Francisco, Dept Radiol, San Francisco, CA 94143 USA
Schuff, Norbert
;
Truran-Sacrey, Diana
论文数: 0引用数: 0
h-index: 0
机构:
Vet Affairs Med Ctr, Ctr Imaging Neurodegenerat Dis, San Francisco, CA 94121 USAUniv Calif San Francisco, Dept Radiol, San Francisco, CA 94143 USA
Truran-Sacrey, Diana
;
Raptentsetsang, Sky
论文数: 0引用数: 0
h-index: 0
机构:
Vet Affairs Med Ctr, Ctr Imaging Neurodegenerat Dis, San Francisco, CA 94121 USAUniv Calif San Francisco, Dept Radiol, San Francisco, CA 94143 USA
Raptentsetsang, Sky
;
Jack, Clifford R., Jr.
论文数: 0引用数: 0
h-index: 0
机构:
Mayo Clin, Dept Radiol, Rochester, MN USAUniv Calif San Francisco, Dept Radiol, San Francisco, CA 94143 USA
Jack, Clifford R., Jr.
;
Weiner, Michael W.
论文数: 0引用数: 0
h-index: 0
机构:
Univ Calif San Francisco, Dept Radiol, San Francisco, CA 94143 USA
Vet Affairs Med Ctr, Ctr Imaging Neurodegenerat Dis, San Francisco, CA 94121 USAUniv Calif San Francisco, Dept Radiol, San Francisco, CA 94143 USA
机构:
Massachusetts Gen Hosp, Dept Radiol, Athinoula A Martinos Ctr Biomed Imaging, Charlestown, MA 02129 USA
Boston Univ, Sch Med, Dept Anat & Neurobiol, Boston, MA 02118 USAMassachusetts Gen Hosp, Dept Radiol, Athinoula A Martinos Ctr Biomed Imaging, Charlestown, MA 02129 USA
Desikan, Rahul S.
;
Cabral, Howard J.
论文数: 0引用数: 0
h-index: 0
机构:
Boston Univ, Sch Publ Hlth, Dept Biostat, Boston, MA USAMassachusetts Gen Hosp, Dept Radiol, Athinoula A Martinos Ctr Biomed Imaging, Charlestown, MA 02129 USA
Cabral, Howard J.
;
Hess, Christopher P.
论文数: 0引用数: 0
h-index: 0
机构:
Univ Calif San Francisco, Dept Radiol, San Francisco, CA 94143 USAMassachusetts Gen Hosp, Dept Radiol, Athinoula A Martinos Ctr Biomed Imaging, Charlestown, MA 02129 USA
Hess, Christopher P.
;
Dillon, William P.
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h-index: 0
机构:
Univ Calif San Francisco, Dept Radiol, San Francisco, CA 94143 USAMassachusetts Gen Hosp, Dept Radiol, Athinoula A Martinos Ctr Biomed Imaging, Charlestown, MA 02129 USA
Dillon, William P.
;
Glastonbury, Christine M.
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h-index: 0
机构:
Univ Calif San Francisco, Dept Radiol, San Francisco, CA 94143 USAMassachusetts Gen Hosp, Dept Radiol, Athinoula A Martinos Ctr Biomed Imaging, Charlestown, MA 02129 USA
Glastonbury, Christine M.
;
Weiner, Michael W.
论文数: 0引用数: 0
h-index: 0
机构:
Univ Calif San Francisco, Dept Radiol, San Francisco, CA 94143 USA
Vet Affairs Med Ctr, San Francisco, CA 94121 USAMassachusetts Gen Hosp, Dept Radiol, Athinoula A Martinos Ctr Biomed Imaging, Charlestown, MA 02129 USA
Weiner, Michael W.
;
Schmansky, Nicholas J.
论文数: 0引用数: 0
h-index: 0
机构:
Massachusetts Gen Hosp, Dept Radiol, Athinoula A Martinos Ctr Biomed Imaging, Charlestown, MA 02129 USAMassachusetts Gen Hosp, Dept Radiol, Athinoula A Martinos Ctr Biomed Imaging, Charlestown, MA 02129 USA
Schmansky, Nicholas J.
;
Greve, Douglas N.
论文数: 0引用数: 0
h-index: 0
机构:
Massachusetts Gen Hosp, Dept Radiol, Athinoula A Martinos Ctr Biomed Imaging, Charlestown, MA 02129 USAMassachusetts Gen Hosp, Dept Radiol, Athinoula A Martinos Ctr Biomed Imaging, Charlestown, MA 02129 USA
Greve, Douglas N.
;
Salat, David H.
论文数: 0引用数: 0
h-index: 0
机构:
Massachusetts Gen Hosp, Dept Radiol, Athinoula A Martinos Ctr Biomed Imaging, Charlestown, MA 02129 USAMassachusetts Gen Hosp, Dept Radiol, Athinoula A Martinos Ctr Biomed Imaging, Charlestown, MA 02129 USA
Salat, David H.
;
Buckner, Randy L.
论文数: 0引用数: 0
h-index: 0
机构:
Massachusetts Gen Hosp, Dept Radiol, Athinoula A Martinos Ctr Biomed Imaging, Charlestown, MA 02129 USA
Harvard Univ, Dept Psychol, Cambridge, MA 02138 USA
Howard Hughes Med Inst, Chevy Chase, MD USA
Massachusetts Gen Hosp, Dept Psychiat, Boston, MA 02114 USAMassachusetts Gen Hosp, Dept Radiol, Athinoula A Martinos Ctr Biomed Imaging, Charlestown, MA 02129 USA
Buckner, Randy L.
;
Fischl, Bruce
论文数: 0引用数: 0
h-index: 0
机构:
Massachusetts Gen Hosp, Dept Radiol, Athinoula A Martinos Ctr Biomed Imaging, Charlestown, MA 02129 USA
MIT, CSAIL, Cambridge, MA 02139 USA
MIT, Harvard Mit Div Hlth Sci & Technol, Cambridge, MA 02139 USAMassachusetts Gen Hosp, Dept Radiol, Athinoula A Martinos Ctr Biomed Imaging, Charlestown, MA 02129 USA