Occupational Liver Injury Due to N,N-Dimethylformamide in the Synthetics Industry

被引：35

作者：

Hamada, Maho ^{[1
]}

Abe, Masanori ^{[1
]}

Tokumoto, Yoshio ^{[1
]}

Miyake, Teruki ^{[1
]}

Murakami, Hidehiro ^{[1
]}

Hiasa, Yoichi ^{[1
]}

Matsuura, Bunzo ^{[1
]}

Sato, Kohei ^{[2
]}

Onji, Morikazu ^{[1
]}

机构：

[1] Ehime Univ, Grad Sch Med, Dept Gastroenterol & Metabol, To On, Ehime, Japan

[2] Kyoritsu Hosp, Dept Internal Med, Saijo, Japan

来源：

INTERNAL MEDICINE | 2009年 / 48卷 / 18期

关键词：

occupational liver injury; synthetics industry; N; N-dimethylformamide; N-METHYLFORMAMIDE; LEATHER WORKERS; DIMETHYLFORMAMIDE; EXPOSURE; HEPATOTOXICITY;

D O I：

10.2169/internalmedicine.48.2332

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

N,N-dimethylformamide (DMF) is a solvent used extensively in the chemical industry. The main toxic effect reported after exposure to DMF is hepatotoxicity. We encountered four patients with liver injury due to DMF exposure; the severity of the liver injury was related to the exposure levels. After removal of exposure, all patients recovered without specific treatment. A careful evaluation of occupational history is necessary when liver dysfunction develops in industrial workers.

引用

页码：1647 / 1650

页数：4

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