Effect of early life physical growth on midlife vertebral dimensions - The Northern Finland Birth Cohort 1966 study

被引：13

作者：

Oura, Petteri ^{[1
,2
,3
]}

Paananen, Markus ^{[1
,2
]}

Ojaniemi, Marja ^{[4
,5
]}

Auvinen, Juha ^{[1
,2
]}

Junno, Juho-Antti ^{[1
,2
,6
,7
]}

Karppinen, Jaro ^{[1
,2
,8
]}

Niinimaki, Jaakko ^{[1
,3
]}

机构：

[1] Univ Oulu, Oulu Univ Hosp, Med Res Ctr Oulu, POB 5000, FI-90014 Oulu, Finland

[2] Univ Oulu, Ctr Life Course Hlth Res, Fac Med, POB 5000, FI-90014 Oulu, Finland

[3] Univ Oulu, Res Unit Med Imaging Phys & Technol, Fac Med, POB 5000, FI-90014 Oulu, Finland

[4] Univ Oulu, PEDEGO Res Unit, Fac Med, POB 5000, FI-90014 Oulu, Finland

[5] Oulu Univ Hosp, Dept Children & Adolescents, POB 23, FI-90029 Oulu, Finland

[6] Univ Oulu, Canc & Translat Med Res Unit, Fac Med, POB 5000, FI-90014 Oulu, Finland

[7] Univ Oulu, Dept Archaeol, Fac Humanities, POB 8000, FI-90014 Oulu, Finland

[8] Kastelli Res Ctr, Finnish Inst Occupat Hlth, Aapistie 1, FI-90220 Oulu, Finland

来源：

BONE | 2017年 / 101卷

基金：

芬兰科学院;

关键词：

Osteoporosis; General population studies; Magnetic resonance imaging; Vertebral size; Lumbar spine; Aging; BONE-MINERAL DENSITY; SEX-DIFFERENCES; LUMBAR SPINE; WEIGHT-GAIN; OSTEOPOROSIS; MASS; CHILDHOOD; ADULTHOOD; PUBERTY; SIZE;

D O I：

10.1016/j.bone.2017.05.006

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Small vertebral size is an independent risk factor for osteoporotic vertebral fractures. Physical growth in early life is related to bone health in later life, but the relationship of early growth versus vertebral size has been inconclusively studied. Utilizing the Northern Finland Birth Cohort 1966 with a 47-year follow-up, we investigated how physical growth in early life is associated with midlife vertebral dimensions. We obtained several physical growth parameters of 1) birth (gestational age, length, weight, BMI), 2) infancy and childhood (peak height velocity (PHV), peak weight velocity (PWV), adiposity peak (AP), adiposity rebound (AR)), and 3) puberty (BMI at growth spurt take-off (TO), PHV, height change). We also studied 4) the ages at which AP, AR, pubertal TO and pubertal PHV occurred. The outcome variable, vertebral cross-sectional area (CSA), was obtained from magnetic resonance imaging scans at the mean age of 46.7 years (n = 517). Sex-stratified linear regression analyses were used with adjustments for gestational age, smoking, and education. Birth length/weight/BMI, and adult height/weight/BMI were also used as covariates, depending on the model. According to our results, birth weight (p <= 0.006) and infant PWV (p <= 0.001) were positively associated with midlife vertebral CSA among both sexes. Length/height variables were associated with vertebral size only before including adult height in the models, and became non-significant thereafter. Among women, BM's at birth, AP, AR, and pubertal TO were positively associated with midlife vertebral CSA (p < 0.05), whereas among men, only high BMI at AR was associated with large vertebral size (p = 0.028). Gestational age and timing of growth were not associated with future vertebral CSA. We conclude that early life weight gain is positively associated with midlife vertebral CSA, and suggest that adult height may mediate the effect of height gain on vertebral size. (C) 2017 Elsevier Inc. All rights reserved.

引用

页码：172 / 178

页数：7

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