Diabetes, Pancreatogenic Diabetes, and Pancreatic Cancer

被引：354

作者：

Andersen, Dana K. ^{[1
]}

Korc, Murray ^{[2
,3
,4
,5
]}

Petersen, Gloria M. ^{[6
]}

Eibl, Guido ^{[7
]}

Li, Donghui ^{[8
]}

Rickels, Michael R. ^{[9
]}

Chari, Suresh T. ^{[10
]}

Abbruzzese, James L. ^{[11
]}

机构：

[1] NIDDK, Div Digest Dis & Nutr, NIH, Bethesda, MD 20892 USA

[2] Indiana Univ Sch Med, Dept Med, Div Endocrinol, Indianapolis, IN 46202 USA

[3] Indiana Univ Sch Med, Dept Biochem & Mol Biol, Indianapolis, IN 46202 USA

[4] Indiana Univ, Melvin & Bren Simon Canc Ctr, Indianapolis, IN 46204 USA

[5] Pancreat Canc Signature Ctr, Indianapolis, IN USA

[6] Mayo Clin, Dept Hlth Sci Res, Rochester, MN USA

[7] Univ Calif Los Angeles, David Geffen Sch Med, Dept Surg, Los Angeles, CA 90095 USA

[8] Univ Texas MD Anderson Canc Ctr, Dept Gastrointestinal Med Oncol, Houston, TX 77030 USA

[9] Univ Penn, Dept Med, Div Endocrinol Diabet & Metab, Perelman Sch Med, Philadelphia, PA 19104 USA

[10] Mayo Clin, Dept Med, Div Gastroenterol & Hepatol, Rochester, MN USA

[11] Duke Univ, Med Ctr, Dept Med, Div Med Oncol, Durham, NC 27710 USA

来源：

DIABETES | 2017年 / 66卷 / 05期

基金：

美国国家卫生研究院;

关键词：

HIGH-FAT; MELLITUS SECONDARY; INSULIN-RESISTANCE; RISK; PREVALENCE; OBESITY; 3C; PREDISPOSITION; METAANALYSIS; PROGRESSION;

D O I：

10.2337/db16-1477

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

The relationships between diabetes and pancreatic ductal adenocarcinoma (PDAC) are complex. Longstanding type 2 diabetes (T2DM) is a risk factor for pancreatic cancer, but increasing epidemiological data point to PDAC as also a cause of diabetes due to unknown mechanisms. New-onset diabetes is of particular interest to the oncology community as the differentiation of new-onset diabetes caused by PDAC as distinct from T2DM may allow for earlier diagnosis of PDAC. To address these relationships and raise awareness of the relationships between PDAC and diabetes, a symposium entitled Diabetes, Pancreatogenic Diabetes, and Pancreatic Cancer was held at the American Diabetes Association's 76th Scientific Sessions in June 2016. This article summarizes the data presented at that symposium, describing the current understanding of the interrelationships between diabetes, diabetes management, and pancreatic cancer, and identifies areas where additional research is needed.

引用

页码：1103 / 1110

页数：8

共 49 条

[1] Prevalence of Diabetes Mellitus in Pancreatic Cancer Compared to Common Cancers [J].

Aggarwal, Gaurav ;

Kamada, Pratima ;

Chari, Suresh T. .

PANCREAS, 2013, 42 (02) :198-201

[2] The practical importance of recognizing pancreatogenic or type 3c diabetes [J].

Andersen, Dana K. .

DIABETES-METABOLISM RESEARCH AND REVIEWS, 2012, 28 (04) :326-328

[3] Pancreatic cancer-derived S-100A8 N-terminal peptide: A diabetes cause? [J].

Basso, Daniela ;

Greco, Eliana ;

Fogar, Paola ;

Pucci, Piero ;

Flagiello, Angela ;

Baldo, Goretta ;

Giunco, Silvia ;

Valerio, Anna ;

Navaglia, Filippo ;

Zambon, Carlo-Fedenco ;

Falda, Alessandra ;

Pedrazzoli, Sergio ;

Plebani, Mario .

CLINICA CHIMICA ACTA, 2006, 372 (1-2) :120-128

[4] Cancer Risk for Patients Using Thiazolidinediones for Type 2 Diabetes: A Meta-Analysis [J].

Bosetti, Cristina ;

Rosato, Valentina ;

Buniato, Danilo ;

Zambon, Antonella ;

La Vecchia, Carlo ;

Corrao, Giovanni .

ONCOLOGIST, 2013, 18 (02) :148-156

[5] Insulin use and cancer risk in patients with type 2 diabetes: A systematic review and meta-analysis of observational studies [J].

Colmers, I. N. ;

Bowker, S. L. ;

Tjosvold, L. A. ;

Johnson, J. A. .

DIABETES & METABOLISM, 2012, 38 (06) :485-506

[6] Pancreatogenic Diabetes: Special Considerations for Management [J].

Cui, YunFeng ;

Andersen, Dana K. .

PANCREATOLOGY, 2011, 11 (03) :279-294

[7] Relationship between the exocrine and endocrine pancreas after acute pancreatitis [J].

Das, Stephanie L. M. ;

Kennedy, James I. C. ;

Murphy, Rinki ;

Phillips, Anthony R. J. ;

Windsor, John A. ;

Petrov, Maxim S. .

WORLD JOURNAL OF GASTROENTEROLOGY, 2014, 20 (45) :17196-17205

[8] High-Fat, High-Calorie Diet Promotes Early Pancreatic Neoplasia in the Conditional KrasG12D Mouse Model [J].

Dawson, David W. ;

Hertzer, Kathleen ;

Moro, Aune ;

Donald, Graham ;

Chang, Hui-Hua ;

Go, Vay Liang ;

Pandol, Steven J. ;

Lugea, Aurelia ;

Gukovskaya, Anna S. ;

Li, Gang ;

Hines, Oscar J. ;

Rozengurt, Enrique ;

Eibl, Guido .

CANCER PREVENTION RESEARCH, 2013, 6 (10) :1064-1073

[9]

DOMSCHKE S, 1985, HEPATO-GASTROENTEROL, V32, P27

[10] Genetic predisposition for beta cell fragility underlies type 1 and type 2 diabetes [J].

Dooley, James ;

Tian, Lei ;

Schonefeldt, Susann ;

Delghingaro-Augusto, Viviane ;

Garcia-Perez, Josselyn E. ;

Pasciuto, Emanuela ;

Di Marino, Daniele ;

Carr, Edward J. ;

Oskolkov, Nikolay ;

Lyssenko, Valeriya ;

Franckaert, Dean ;

Lagou, Vasiliki ;

Overbergh, Lut ;

Vandenbussche, Jonathan ;

Allemeersch, Joke ;

Chabot-Roy, Genevieve ;

Dahlstrom, Jane E. ;

Laybutt, D. Ross ;

Petrovsky, Nikolai ;

Socha, Luis ;

Gevaert, Kris ;

Jetten, Anton M. ;

Lambrechts, Diether ;

Linterman, Michelle A. ;

Goodnow, Chris C. ;

Nolan, Christopher J. ;

Lesage, Sylvie ;

Schlenner, Susan M. ;

Liston, Adrian .

NATURE GENETICS, 2016, 48 (05) :519-+

← 1 2 3 4 5 →