Direct reductive amination of aldehydes and ketones mediated by a thiourea derivative as an organocatalyst

被引：12

作者：

Huang, Yi-Bo ^{[1
]}

Cai, Chun ^{[1
]}

机构：

[1] Nanjing Univ Sci & Technol, Sch Chem Engn, Nanjing 210094, Peoples R China

来源：

JOURNAL OF CHEMICAL RESEARCH | 2009年 / 11期

关键词：

thiourea derivative; reduction; organocatalyst; hydrogen bond; amination; TRANSFER HYDROGENATION; CYANOHYDRIDOBORATE;

D O I：

10.3184/030823409X12561332783406

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

The direct reductive arylamination of arylaldehydes and ketones has been achieved using a selective imine activation by a hydrogen bond of a thiourea derivative. This mild, acid- and metal-free process requires a catalytic amount of N,N'-bis[3,5-bis(trifluoromethyl)phenyl]thiourea, the Hantzsch 1,4- dihydropydine diethyl 1,4-dihydro-2,6-dimethyl-3,5-pyridinedicarboxylate as hydride source and activated 5 angstrom-molecule sieve as dehydrant. The method is adaptable for the synthesis of various amines.

引用

页码：686 / 688

页数：3

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