A hit-and-run heat shock factor governs sustained histone methylation and transcriptional stress memory

被引:308
作者
Laemke, Joern [1 ]
Brzezinka, Krzysztof [1 ]
Altmann, Simone [1 ]
Baeurle, Isabel [1 ]
机构
[1] Univ Potsdam, Inst Biochem & Biol, Potsdam, Germany
关键词
chromatin; H3K4; methylation; heat shock transcription factor; priming; transcriptional memory; ACQUIRED THERMOTOLERANCE; EPIGENETIC MEMORY; CHROMATIN CHANGES; GENE LOOPS; ARABIDOPSIS; HSFA2; TOLERANCE; PLANTS; TRIMETHYLATION; MECHANISMS;
D O I
10.15252/embj.201592593
中图分类号
Q5 [生物化学]; Q7 [分子生物学];
学科分类号
071010 ; 081704 ;
摘要
In nature, plants often encounter chronic or recurring stressful conditions. Recent results indicate that plants can remember a past exposure to stress to be better prepared for a future stress incident. However, the molecular basis of this is poorly understood. Here, we report the involvement of chromatin modifications in the maintenance of acquired thermotolerance (heat stress [HS] memory). HS memory is associated with the accumulation of histone H3 lysine 4 di- and trimethylation at memory-related loci. This accumulation outlasts their transcriptional activity and marks them as recently transcriptionally active. High accumulation of H3K4 methylation is associated with hyper-induction of gene expression upon a recurring HS. This transcriptional memory and the sustained accumulation of H3K4 methylation depend on HSFA2, a transcription factor that is required for HS memory, but not initial heat responses. Interestingly, HSFA2 associates with memory-related loci transiently during the early stages following HS. In summary, we show that transcriptional memory after HS is associated with sustained H3K4 hyper-methylation and depends on a hit-and-run transcription factor, thus providing a molecular framework for HS memory.
引用
收藏
页码:162 / 175
页数:14
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