Recent advances bioactive 1,2,4-triazole-3-thiones

被引：216
作者：
Kucukguzel, S. Guniz [1 ]
Cikla-Suzgun, Pelin [1 ]
机构：
[1] Marmara Univ, Fac Pharm, Dept Pharmaceut Chem, TR-34668 Istanbul, Turkey
来源：
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY | 2015年 / 97卷
关键词：
1,2,4-Triazole-3-thione; Ribavirin; Fluconazole; Anastrozole; Etodolac 1,2,4-triazole; Diflunisal 1,2,4-triazole; CLASSICAL ANTIEPILEPTIC DRUGS; INDUCED SEIZURE MODEL; ANTIMICROBIAL ACTIVITIES; MANNICH-BASES; 1,3,4-THIADIAZOLE DERIVATIVES; BIOLOGICAL EVALUATION; UREASE INHIBITION; ANTIINFLAMMATORY ACTIVITIES; ANTICONVULSANT ACTIVITY; ANTIBACTERIAL ACTIVITY;
D O I：
10.1016/j.ejmech.2014.11.033
中图分类号：
R914 [药物化学];
学科分类号：
100701 ;
摘要：
Triazoles are heterocyclic compounds which have a five-membered ring of two carbon atoms and three nitrogen atoms. These structures have been interest in the development of novel compounds with anticonvulsant, antidepressant, antioxidant, anti-inflammatory, analgesic, antinociceptive, antibacterial, antimycobacterial, antifungal, antiviral, anticancer, anti-parasitic, anti-urease and other activities. Therefore, many researchers have synthesized these compounds as target structures and evaluated their biological activities. This review contains various pharmacological activities of 1,2,4-triazole-3-thiones in one place and it is also the milestone for the new research towards this moiety. (C) 2014 Elsevier Masson SAS. All rights reserved.
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收藏
页码：830 / 870
页数：41
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