A multi-center randomized prospective study on the treatment of infant bronchiolitis with interferon α1b nebulization

被引：29

作者：

Chen, Lina ^{[1
,2
]}

Shi, Mingfang ^{[3
]}

Deng, Quanmin ^{[4
]}

Liu, Wenjun ^{[5
]}

Li, Qin ^{[6
]}

Ye, Piao ^{[7
]}

Yu, Xiahui ^{[8
]}

Zhang, Benjin ^{[9
]}

Xu, Yuxia ^{[10
]}

Li, Xiaolan ^{[11
]}

Yang, Yao ^{[12
]}

Li, Min ^{[13
,14
]}

Yan, Yi ^{[15
]}

Xu, Zhe ^{[16
]}

Yu, Jing ^{[17
]}

Xiang, Long ^{[18
]}

Tang, Xiaojun ^{[19
]}

Wan, Guangping ^{[20
]}

Cai, Qiang ^{[21
]}

Wang, Li ^{[22
]}

Hu, Bo ^{[23
]}

Xie, Liang ^{[1
,2
]}

Li, Gen ^{[24
]}

Xie, Lunyan ^{[3
]}

Liu, Xiaoyun ^{[4
]}

Liu, Chunyan ^{[5
]}

Li, Li ^{[6
]}

Chen, Lijie ^{[7
]}

Jiang, Xiaobin ^{[8
]}

Huang, Yana ^{[9
]}

Wang, Si ^{[10
]}

Guo, Jiang ^{[11
]}

Shi, Yan ^{[12
]}

Wang, Xiaofang ^{[15
]}

Zhao, Zhiyong ^{[16
]}

Li, Yan ^{[17
]}

Liu, Yanru ^{[24
]}

Fu, Qiang ^{[3
]}

Zeng, Yan ^{[4
]}

Zou, Yan ^{[5
]}

Liu, Dingyuan ^{[6
]}

Wan, Deyun ^{[25
]}

Ai, Tao ^{[25
]}

Liu, Hanmin ^{[1
,2
]}

机构：

[1] Sichuan Univ, West China Univ Hosp 2, Dept Pediat Pulmonol & Immunol, Chengdu, Peoples R China

[2] Sichuan Univ, Minist Educ, Key Lab Birth Defects & Related Dis Women & Child, West China Univ Hosp 2, Chengdu, Peoples R China

[3] First Peoples Hosp Yibin City, Yibin, Peoples R China

[4] Peoples Hosp Deyang City, Deyang, Peoples R China

[5] Southwest Med Univ, Affiliated Hosp, Luzhou, Peoples R China

[6] Suining Cent Hosp, Suining, Peoples R China

[7] Sichuan Prov Hosp Women & Children, Chengdu, Peoples R China

[8] Chongzhou City Peoples Hosp, Chongzhou, Peoples R China

[9] Dazhou Cent Hosp, Dazhou, Peoples R China

[10] North Sichuan Med Coll, Affiliated Hosp, Nanchong, Peoples R China

[11] Panzhihua Cent Hosp, Panzhihua, Peoples R China

[12] Liangshan First Peoples Hosp, Xichang, Peoples R China

[13] Sichuan Acad Med Sci, Chengdu, Peoples R China

[14] Sichuan Prov Peoples Hosp, Chengdu, Peoples R China

[15] First Peoples Hosp Neijiang, Neijiang, Peoples R China

[16] Guangyuan Cent Hosp, Guangyuan, Peoples R China

[17] Mianyang Cent Hosp, Mianyang, Sichuan, Peoples R China

[18] Chengdu First Peoples Hosp, Chengdu, Peoples R China

[19] Jianyang City Peoples Hosp, Jianyang, Peoples R China

[20] Meishan City Peoples Hosp, Meishan, Peoples R China

[21] Second Peoples Hosp Yibin, Yibin, Peoples R China

[22] Peoples Hosp Leshan, Leshan, Peoples R China

[23] Chengdu Fifth Peoples Hosp, Chengdu, Peoples R China

[24] Chengdu Womens & Childrens Cent Hosp, Chengdu, Peoples R China

[25] Sinosource Biopharmaceut Inc, Chengdu, Peoples R China

来源：

PLOS ONE | 2020年 / 15卷 / 02期

关键词：

D O I：

10.1371/journal.pone.0228391

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

Background The respiratory syncytial virus (RSV) is the main cause of bronchiolitis in infants and interferon (IFN) alpha is a commercial antiviral drug. The nebulization of IFN alpha 1b could be a viable treatment method. In this study, the therapeutic effects and safety of IFN alpha 1b delivery via nebulization in infant bronchiolitis were investigated in this multi-center prospective study. Methods and findings Bronchiolitis patients admitted to 22 hospitals who met the inclusion criteria were enrolled and randomly allocated to four groups: control, IFN Intramuscular Injection, IFN Nebulization 1 (1 mu g/kg), and IFN Nebulization 2 (2 mu g/kg) groups. All patients were observed for 7 days. The therapeutic effects and safety of different IFN delivery doses and delivery modes were evaluated. Coughing severity change, as scored by the researchers and parents, between days 1 and 3 was significantly different between the IFN Nebulization 2 and control groups. Lowell wheezing score change between days 3 and 5 was significantly different between IFN Nebulization 1 and control groups. There were no significant differences among the four groups regarding the number of consecutive days with fever, three-concave sign, fatigue and sleepiness, and loss of appetite. There were no cases of severe complications, no recurrence of fever, and no regression of mental status. Conclusions IFN-alpha 1b could more effectively alleviate coughing and wheezing in bronchiolitis. IFN-alpha 1b nebulization had significant advantages in shortening the duration of wheezing and alleviating coughing.

引用

页数：11

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