mRNA COVID-19 vaccine effectiveness against SARS-CoV-2 infection in a prospective community cohort, rural Wisconsin, November 2020 to December 2021

被引：6

作者：

McLean, Huong Q. ^{[1
]}

McClure, David L. ^{[1
]}

King, Jennifer P. ^{[1
]}

Meece, Jennifer K. ^{[1
]}

Pattinson, David ^{[2
]}

Neumann, Gabriele ^{[2
]}

Kawaoka, Yoshihiro ^{[2
]}

Rolfes, Melissa A. ^{[3
]}

Belongia, Edward A. ^{[1
]}

机构：

[1] Marshfield Clin Res Inst, Marshfield, WI USA

[2] Univ Wisconsin, Sch Vet Med, Dept Pathobiol Sci, Madison, WI 53706 USA

[3] Ctr Dis Control & Prevent, Atlanta, GA USA

来源：

INFLUENZA AND OTHER RESPIRATORY VIRUSES | 2022年 / 16卷 / 04期

关键词：

COVID-19; SARS-CoV-2; vaccine effectiveness;

D O I：

10.1111/irv.12970

中图分类号：

R51 [传染病];

学科分类号：

100401 ;

摘要：

Reduced COVID-19 vaccine effectiveness (VE) has been observed with increasing predominance of SARS-CoV-2 Delta (B.1.617.2) variant. Two-dose VE against laboratory-confirmed SARS-CoV-2 infection (symptomatic and asymptomatic) was estimated using Cox proportional hazards models with time-varying vaccination status in a prospective rural community cohort of 1266 participants aged >= 12 years. Between November 3, 2020 and December 7, 2021, VE was 56% for mRNA COVID-19 vaccines overall, 65% for Moderna, and 50% for Pfizer-BioNTech. VE when Delta predominated (June to December 2021) was 54% for mRNA COVID-19 vaccines overall, 59% for Moderna, and 52% for Pfizer-BioNTech.

引用

页码：607 / 612

页数：6

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